Table 2

Phenotype associations in male and female patients

MenWomen
RL (n=590)RN (n=122)LN (n=9)2-sinus (n=73)P valueRL (n=179)RN (n=47)2-sinus (n=23)P value
Age, years55.5±13.855.7±13.551.8±20.251.3±13.70.08061.0±11.459.3±12.656.0±9.60.125
BSA, m22.06±0.192.05±0.191.92±0.202.07±0.200.1361.82±0.201.78±0.201.78±0.150.434
Hypertension, n (%)255 (43.2)48 (39.3)3 (33.3)24 (32.9)0.33779 (44.1)17 (36.2)11 (47.8)0.547
Diabetes, n (%; n=583)29 (9.3)4 (5.4)1 (20.0)2 (5.9)0.40010 (8.8)5 (15.6)1 (8.3)0.492
Dyslipidaemia, n (%)72 (12.2)17 (13.9)3 (33.3)8 (11.0)0.26422 (12.3)6 (12.8)5 (21.7)0.436
Valve disease
 Aortic valve stenosis, n (%)351 (59.5)85 (69.7)5 (55.6)50 (68.5)0.104146 (81.6)37 (78.7)20 (87.0)0.742
 Aortic valve insufficiency, n (%)201 (34.1)31 (25.4)4 (44.4)16 (21.9)0.04713 (7.3)*10 (21.3)*1 (4.3)0.017
 Dilatation only, n (%)38 (6.4)6 (4.9)0 (0.0)7 (9.6)0.56520 (11.2)*0 (0.0)*2 (8.7)0.026
Aortic dimensions†
 Annulus, cm2.7±0.4 (n=421)2.6±0.3 (n=90)2.6±0.3 (n=8)2.7±0.3 (n=55)0.2712.3±0.4 (n=133)2.3±0.3 (n=40)2.1±0.2 (n=19)0.060
 Sinus of Valsalva, cm3.8±0.6 (n=495)*3.6±0.5 (n=101)*3.5 ±+0.3 (n=8)3.7±0.6 (n=62)0.0023.3±0.6 (n=156)*3.2±0.5 (n=41)2.9±0.5 (n=22)*0.024
 Sinotubular junction, cm3.3±0.6 (n=412)*3.1±0.5 (n=87)*3.1±0.5 (n=7)3.2±0.5 (n=55)0.0482.9±0.6 (n=137)2.7±0.4 (n=36)2.7±0.5 (n=19)0.409
 Ascending aorta, cm4.2±0.9 (n=515)4.0±0.7 (n=107)3.8±0.7 (n=8)4.3±0.7 (n=64)0.1164.1±0.8 (n=159)3.9±0.8 (n=43)3.7±0.8 (n=21)0.089
Aortopathy
 Any dilatation, n (%; n=1003)222 (39.2)33 (28.7)1 (11.1)28 (39.4)0.06552 (30.2)9 (20.5)5 (21.7)0.347
 Ascending phenotype, n (%)160 (28.2)27 (23.5)1 (11.1)20 (28.2)0.56948 (27.9)9 (20.5)5 (21.7)0.536
 Root phenotype, n (%)13 (2.3)0 (0.0)*0 (0.0)5 (7.0)0.0311 (0.6)0 (0.0)0 (0.0)1.000
 Root extended, n (%)49 (8.6)6 (5.2)0 (0.0)3 (4.2)0.4333 (1.7)0 (0.0)0 (0.0)1.000
  • *Groups are significantly different after Bonferroni corrections for multiple comparisons.

  • †P values adjusted for age and BSA.

  • BSA, body surface area; LN, left-non-coronary fusion; ; RL, right–left fusion; RN, right-non-coronary fusion.