Table 2

Multivariable Cox regression analysis according to the different antithombotic regimens to define (A) the composite endpoint of ICU admission, invasive mechanical ventilation, and death (B) ICU admission (C) invasive mechanical ventilation (D) in-hospital all cause mortality

	aHR	95.0% CI for aHR
	aHR	Lower	Upper	P value
Composite of ICU admission, invasive mechanical ventilation, and death
Prophylactic anticoagulation				0.033
Therapeutic anticoagulation	0.84	0.302	2.336	0.738
Prophylactic anticoagulation + antiplatelet therapy	0.505	0.197	1.296	0.155
Therapeutic anticoagulation + antiplatelet therapy	1.434	0.615	3.344	0.404
Hypertension	2.568	1.429	4.617	0.002
Tocilizumab	2.132	1.071	4.244	0.031
Admission oxygen saturation	0.954	0.936	0.973	0
Interlukin-6	1	1	1.001	0.026
Predicted probability anticoagulant prescription	0.528	0.06	4.648	0.565
Predicted probability antiplatelt prescription	1.195	0.282	5.071	0.809
ICU admission
Prophylactic anticoagulation				0.035
Therapeutic anticoagulation	0.831	0.28	2.466	0.739
Prophylactic anticoagulation + antiplatelet therapy	0.566	0.212	1.515	0.257
Therapeutic anticoagulation + antiplatelet therapy	1.569	0.644	3.821	0.321
Hypertension	2.331	1.284	4.232	0.005
Tocilizumab	2.308	1.154	4.619	0.018
Admission oxygen saturation	0.953	0.934	0.971	0
Interlukin-6	1	1	1.001	0.031
Predicted probability anticoagulant prescription	0.226	0.021	2.386	0.216
Predicted probability antiplatelt prescription	1.412	0.32	6.236	0.649
Invasive mechanical ventilation
Prophylactic anticoagulation				0.005
Therapeutic anticoagulation	0.629	0.15	2.628	0.525
Prophylactic anticoagulation + antiplatelet therapy	0.07	0.014	0.351	0.001
Therapeutic anticoagulation + antiplatelet therapy	0.359	0.099	1.309	0.121
Gender	5.02	1.911	13.182	0.001
Hypertension	3.343	1.259	8.876	0.015
Steroids	439943.283	0	.	0.978
Admission oxygen saturation	0.888	0.858	0.919	0
Predicted probability anticoagulant prescription	0.005	0	0.177	9.004
Predicted probability antiplatelt prescription	135.695	7.786	2365.045	0.001
D-dimers	1.136	0.994	1.297	0.061
Interlukin-6	1.001	1	1.001	0.001
In hospital all cause mortality
Prophylactic anticoagulation				0.014
Therapeutic anticoagulation	0.126	0.028	0.573	0.007
Prophylactic anticoagulation + antiplatelet therapy	0.41	0.103	1.634	0.206
Therapeutic anticoagulation + antiplatelet therapy	0.113	0.028	0.449	0.002
Weight	0.974	0.949	1	0.048
Hypertension	3.684	1.211	11.209	0.022
Steroids	73168.344	0	.	0.982
Tofacitinib	2.516	0.872	7.263	0.088
Anticoagulation admission	3.716	1.099	12.571	0.035
Admission oxygen saturation	0.965	0.937	0.994	0.017
Predicted probability anticoagulant prescription	0.947	0.058	15.533	0.97
Predicted probability antiplatelt prescription	6.004	0.641	56.244	0.116
Interlukin-6	1	0.999	1.001	0.877

This Cox regression analysis is adjusted on anticoagulation and antiplatelet regimen, age, smoker, weight, gender, hypertension, dyslipidemia, diabetes, coronary artery disease, steroids, tofacitinib, anticoagulation on admission, immunosuppressant, antiplatelet use on admission, inpatient prescription of any of the following medication, azithromycin, fondaparinux, remdesivir, tocilizumab, oxygen saturation on admission, D-dimers, CRP and interleukin 6, in addition to propensity scores predicted probability of anticoagulant or antiplatelet prescription.
aHR, adjusted hazard ratio; ICU, intensive care unit.