Clinical testing before and after treatment with potassium-elevating treatment in addition to usual treatment
| Treatment regime | Low dose Spironolactone 50 mg N=9 | High dose+ Spironolactone 100 mg+3 g potassium chloride N=10 | ||||
| Time and comparison | Before treatment | After treatment | P value before versus after | Before treatment | After treatment | P value before versus after |
| Blood pressure | ||||||
| Systolic (mm Hg), mean±SD | 117.9±12.0 | 111.9±12.3 | 0.018 | 117.0±9.3 | 110.7±9.9 | 0.022 |
| Diastolic (mm Hg), mean±SD | 74.7±10.9 | 70.6±9.5 | 0.10 | 68.3±6.9 | 66.4±7.1 | 0.30 |
| Blood tests | ||||||
| Potassium (mmol/L), mean±SD | 4.26±0.22 | 4.05±0.19 | 0.072 | 4.08±0.29 | 4.48±0.54 | 0.001 |
| Sodium (mmol/L), mean±SD | 141.7±2.6 | 140.1±2.1 | 0.11 | 141.20±1.48 | 139.60±1.51 | 0.005 |
| Magnesium (mmol/L), mean±SD | 0.87±0.04 | 0.84±0.06 | 0.18 | 0.83±0.06 | 0.81±0.06 | 0.29 |
| Glucose (mmol/L), mean±SD | 5.11±0.50 | 5.50±0.75 | 0.17 | 5.09±0.54 | 5.06±0.74 | 0.89 |
| eGFR (mL/min/1.73 m2), mean±SD | 105.6±16.9 | 97.4±18.3 | 0.043 | 99.0±14.6 | 86.6±14.2 | 0.003 |
| ECG measures—Manuel | ||||||
| HR, baseline, mean±SEM | 50.1±2.3 | 55.0±1.8 | 0.11 | 51.4±2.2 | 53.7±2.0 | 0.42 |
| HR at max heart rate, mean±SEM | 83.1±2.7 | 82.0±4.0 | 0.58 | 73.7±3.0 | 78.4±3.6 | 0.27 |
| ∆HR, max heart rate, mean±SEM | 33.0±2.4 | 27.0±1.9 | <0.001 | 22.3±2.4 | 24.7±3.0 | 0.28 |
| Time from baseline to max heart rate (s), mean±SEM | 9.9±0.8 | 8.9±0.8 | 0.06 | 9.4±0.8 | 10.5±1.1 | 0.33 |
| Fridericia’s correction | ||||||
| QTcF, baseline, mean±SEM | 477.9±7.2 | 478.5±7.3 | 0.94 | 471.9±8.1 | 468.9±8.0 | 0.66 |
| QTcF, max heart rate, mean±SEM | 542.2±8.0 | 536.0±9.4 | 0.39 | 519.9±10.1 | 523.0±12.5 | 0.65 |
| ∆QTcF, max heart rate, mean±SEM | 64.4±3.5 | 57.4±3.7 | 0.11 | 48.0±5.5 | 54.1±8.6 | 0.41 |
| Bazett’s correction | ||||||
| QTcB, baseline, mean±SEM | 463.5±9.7 | 471.5±7.7 | 0.062 | 459.8±10.7 | 460.1±9.5 | 0.98 |
| QTcB, max heart rate, mean±SEM | 571.9±11.3 | 564.4±11.3 | 0.20 | 537.8±12.9 | 546.5±15.3 | 0.47 |
| ∆QTcB, max heart rate, mean±SEM | 108.4±5.8 | 93.0±6.0 | 0.016 | 78.0±7.7 | 86.4±11.8 | 0.36 |
| Automatic—12SL | ||||||
| HR, baseline, mean±SEM | 52.5±2.3 | 57.3±1.8 | 0.06 | 53.6±1.2 | 55.5±1.7 | 0.45 |
| QTcF, baseline, mean±SEM | 490.2±8.1 | 492.9±9.7 | 0.73 | 484.9±7.9 | 483.2±7.4 | 0.66 |
| QTcB, baseline, mean+SEM | 479.2±10.4 | 488.9±9.6 | 0.20 | 475.6±6.8 | 476.7±7.5 | 0.80 |
| MCS, baseline, mean±SEM | 1.551±0.196 | 1.499±0.167 | 0.73 | 1.570±0.237 | 1.651±0.236 | 0.35 |
eGFR, estimated glomerular filtration rate; max, maximum.