Multivariable-adjusted population attributable fraction for AF by age groups
| Population attributable fraction (95% CI) | ||||
| 40–49 years (n=24 914) | 50–59 years (n=21 824) | 60–69 years (n=13 441) | ≥70 years (n=6772) | |
| BMI* | 8.00 (0.43 to 15.56) | 15.32 (7.74 to 22.90) | 18.55 (12.18 to 24.92)† | 3.95 (−1.31 to 9.20) |
| Diabetes | −2.19 (−7.39 to 3.01) | 3.39 (−0.12 to 6.91) | 2.88 (−0.67 to 6.42) | 5.95 (2.21 to 9.68) |
| Daily smoker | 2.32 (−5.64 to 10.28) | 2.95 (−2.60 to 8.50) | 2.57 (−1.35 to 6.48) | 0.08 (−2.49 to 2.66) |
| Hypertension‡ | 15.03 (−1.74 to 31.79) | 10.33 (−2.86 to 23.51) | 19.83 (6.97 to 32.70) | 20.03 (3.82 to 36.25) |
| Total serum cholesterol§ | −5.54 (−12.25 to 1.17) | −8.94 (−15.63 to −2.25) | −4.93 (−11.04 to 1.17) | −2.98 (−8.97 to 3.00) |
| Average daily alcohol consumption¶ | 6.75 (−0.89 to 14.39) | 1.84 (−3.33 to 7.00) | 3.41 (0.12 to 6.70) | −2.39 (−5.41 to 0.63) |
| History of MI or stroke | 4.49 (0.28 to 8.69) | 6.54 (1.62 to 11.46) | 7.34 (3.63 to 11.04) | 9.88 (5.89 to 13.87) |
Adjusted for age, sex, BMI, total serum cholesterol, daily smoking, diabetes, hypertension, daily alcohol consumption and study site.
*Reference category ≤30 kg/m2.
†Significantly different from age ≥70, p=0.002; all other between-group p>0.008.
‡Systolic blood pressure ≥140 mm Hg and/or taking antihypertensive drugs.
§Reference category ≤6.5 mmol/L.
¶Reference category <20 g for women,<40 g for men.
AF, atrial fibrillation; BMI, body mass index; MI, myocardial infarction.