Multivariable-adjusted HR for AF by age groups
| Multivariable-adjusted HR for AF | ||||
| 40–49 years (n=24 914) | 50–59 years (n=21 824) | 60–69 years (n=13 441) | ≥70 years (n=6772) | |
| BMI (per 5 kg/m2 increase) | 1.41 (1.18 to 1.68,<0.001) | 1.37 (1.23 to 1.53,<0.001) | 1.37 (1.25 to 1.50,<0.001) | 1.17 (1.06 to 1.29, 0.001)* |
| Diabetes | 0.57 (0.18 to 1.80, 0.337) | 1.48 (1.04 to 2.09, 0.029) | 1.27 (0.96 to 1.66, 0.090) | 1.59 (1.23 to 2.06,<0.001) |
| Daily smoker | 1.13 (0.79 to 1.63, 0.501) | 1.14 (0.89 to 1.45, 0.305) | 1.16 (0.92 to 1.46, 0.220) | 1.00 (0.78 to 1.27, 0.988) |
| Hypertension† | 1.40 (0.98 to 2.00, 0.068) | 1.19 (0.94 to 1.51, 0.138) | 1.32 (1.07 to 1.64, 0.011) | 1.29 (1.02 to 1.63, 0.035) |
| Total serum cholesterol (per mmol/L increase) | 0.91 (0.78 to 1.06, 0.242) | 0.91 (0.83 to 0.99, 0.039) | 0.89 (0.83 to 0.97, 0.004) | 0.96 (0.89 to 1.03, 0.283) |
| Average daily alcohol consumption (per 20 g increase) | 1.18 (1.02 to 1.36, 0.025) | 1.17 (1.05 to 1.30, 0.005) | 1.13 (1.00 to 1.28, 0.049) | 0.92 (0.79 to 1.08, 0.327)‡ |
| History of MI or stroke | 4.60 (2.56 to 8.27,<0.001)§ | 1.93 (1.40 to 2.67,<0.001) | 1.68 (1.32 to 2.13,<0.001) | 1.57 (1.27 to 1.94,<0.001) |
| eGFR¶ | 1.07 (0.90 to 1.26, 0.430) | 0.93 (0.84 to 1.03, 0.193) | 1.00 (0.92 to 1.09, 0.984) | 0.88 (0.81 to 0.96, 0.005) |
| C reactive protein (mg/L) | 0.94 (0.83 to 1.06, 0.295) | 1.00 (0.97 to 1.03, 0.960) | 1.01 (0.99 to 1.02, 0.245) | 1.01 (0.99 to 1.02, 0.348) |
| Nt-pro-BNP (per 10-fold increase) | 5.51 (2.70 to 11.24,<0.001) | 4.80 (3.29 to 6.98,<0.001) | 5.46 (4.08 to 7.31,<0.001) | 7.58 (5.62–10.24,<0.001) |
Values are HR (95% CI, p value).
Adjusted for age, sex, BMI, total serum cholesterol, daily smoking, diabetes, hypertension, daily alcohol consumption and study site.
*P≤0.033 for difference between ages ≥70, and 50–59 and 60–69, respectively.
†Systolic blood pressure ≥140 mm Hg and/or taking antihypertensive drugs.
‡p≤0.047 for difference between ages ≥70 and the other age groups.
§P≤0.011 for difference between ages 40–49 and the other age groups.
¶Using the Chronic Kidney Disease Epidemiology Collaboration formula with creatinine.
AF, atrial fibrillation; BMI, body mass index; eGFR, estimated glomerular filtration rate; MI, myocardial infarction; Nt-proBN, N-terminal-pro B-type natriuretic peptide.