Risk factor distribution by age groups at baseline
| Risk factor distribution (n=66 951) | ||||
| 40–49 years (n=24 914) | 50–59 years (n=21 824) | 60–69 years (n=13 441) | ≥70 years (n=6772) | |
| BMI (kg/m2) | 25.5 (23.1 to 28.4) | 26.8 (24.2 to 29.8) | 27.5 (24.8 to 30.7) | 27.0 (24.3 to 30.1) |
| <30 | 20 806 (84.0) | 16 418 (75.8) | 9414 (70.6) | 4949 (73.8) |
| ≥30 | 3951 (16.0) | 5250 (24.2) | 3926 (29.4) | 1757 (26.2) |
| Systolic blood pressure (mm Hg)* | 129 (119 to 141) | 138 (125 to 152) | 145 (132 to 160) | 154 (140 to 170) |
| <140 | 18 097 (73.1) | 11 658 (53.8) | 5277 (39.6) | 1667 (24.8) |
| ≥140 | 6656 (26.9) | 10 023 (46.2) | 8058 (60.4) | 5056 (75.2) |
| Diabetes | 539 (2.2) | 1115 (5.1) | 1196 (8.9) | 676 (10.0) |
| Daily smoker | 7802 (31.4) | 5871 (27.0) | 2628 (19.7) | 1004 (15.0) |
| Taking antihypertensive drugs | 1608 (7.0) | 3958 (19.6) | 3989 (31.3) | 2422 (36.9) |
| Hypertension† | 7389 (31.6) | 11 423 (54.7) | 9150 (69.5) | 5508 (82.2) |
| Total serum cholesterol (mmol/L) | 5.7 (5.0 to 6.5) | 6.1 (5.3 to 6.9) | 6.1 (5.3 to 6.9) | 6.1 (5.3 to 7.1) |
| ≤6.5 | 18 830 (76.3) | 14 074 (65.1) | 8556 (64.4) | 4162 (62.3) |
| >6.5 | 5859 (23.7) | 7558 (34.9) | 4721 (35.6) | 2522 (37.7) |
| Average daily alcohol consumption (g) | 3.0 (0.0 to 12.0) | 3.0 (0.0 to 12.0) | 2.0 (0.0 to 11.0) | 2.0 (0.0 to 12.0) |
| History of MI or stroke | 285 (1.1) | 1024 (4.7) | 1255 (9.3) | 1061 (15.7) |
| eGFR‡ | 104.7 (93.9 to 109.3) | 96.9 (85.5 to 101.9) | 89.8 (78.2 to 95.0) | 81.9 (69.9 to 87.9) |
| C reactive protein (mg/L) | 1.0 (0.5 to 2.2) | 1.4 (0.7 to 3.0) | 1.7 (0.9 to 3.6) | 1.9 (1.0 to 3.9) |
| Nt-proBNP (pg/mL) | 35.9 (19.8 to 62.3) | 44.9 (25.1 to 78.9) | 70.8 (40.2 to 125.5) | 126.6 (70.8 to 228.4) |
| log10 (Nt -proBNP (pg/mL)) | 1.6 (1.3 to 1.8) | 1.7 (1.4 to 1.9) | 1.9 (1.6 to 2.1) | 2.1 (1.8 to 2.4) |
Continuous variables are presented as median and IQR (25th and 75th percentile), binary variables as absolute and relative frequencies.
*Mean of two measurements.
†Systolic blood pressure ≥140 mm Hg and/or taking antihypertensive drugs.
‡Using the Chronic Kidney Disease Epidemiology Collaboration formula with creatinine.
BMI, body mass index; eGFR, estimated glomerular filtration rate; MI, myocardial infarction; Nt-pro-BN, N-terminal-pro B-type natriuretic peptide.