Table 2

Endpoint analysis of LV function and structure between baseline and 6 months in whole cohort

Placebo (n=41)CAP-1002 group (n=83)Between-group p value
LVEDVi at baseline, mL/m2105.2 (25.9)102.7 (20.4)0.02
LVEDVi at 6 months, mL/m2110.9 (26.5)103.7 (23.4)
Within-group p value0.0010.41
Change in LVEDVi, mL/m25.7 (10.3)1.0 (11.3)
LVESVi at baseline, mL/m264.8 (22.8)62.5 (18.0)0.08
LVESVi at 6 months, mL/m268.0 (22.9)62.8 (20.2)
Within-group p value0.010.78
Change in LVESVi, mL/m23.1 (7.7)0.3 (9.4)
SVi at baseline, mL/m240.3 (6.6)40.2 (6.2)0.04
SVi at 6 months, mL/m242.9 (7.2)40.9 (6.9)
Within-group p value0.0070.24
Change in SVi, mL/m22.5 (5.7)0.7 (5.7)
LVEF at baseline, %39.7 (7.8)40.0 (6.7)0.93
LVEF at 6 months, %39.3 (8.1)40.4 (7.1)
Within-group p value0.580.38
Change in LVEF, %0.3 (3.4)0.4 (4.4)
CO at baseline, L/min5.8 (1.2)5.3 (1.1)0.92
CO at 6 months, L/min5.7 (1.2)5.3 (1.2)
Within-group p value0.730.98
Change in CO, L/min−0.05 (0.9)−0.001 (0.8)
LVMi at baseline, g/m277.1 (13.6)74.7 (13.5)0.72
LVMi at 6 months, g/m276.5 (13.4)74.3 (12.6)
Within-group p value0.210.27
Change in LVMi, g/m20.6 (3.3)0.4 (3.3)
Scar mass at baseline, g/m237.7 (12.0)34.2 (11.7)0.7
Scar mass at 6 months, g/m236.4 (12.6)32.3 (11.3)
Within-group p value<0.001<0.001
Change in scar mass, g/m2−1.7 (2.8)−1.8 (2.9)
Scar per cent at baseline, %22.9 (5.5)22.0 (5.5)0.43
Scar per cent at 6 months, %22.3 (6.3)20.9 (5.4)
Within-group p value0.01<0.001
Change in scar per cent, %−0.8 (2.1)−1.1 (1.7)
  • Within-group p value refers to the changes from baseline to 6 months within CAP-1002 and placebo groups separately.

  • Between-group p value refers to the relative difference in the slope of change from baseline to 6 months between CAP-1002 and placebo groups (ie, treatment effect in CAP-1002 vs placebo groups).

  • Bold font indicates statistical significance.

  • CO, cardiac output; LV, left ventricle; LVEDVi, left ventricular end-diastolic volume index; LVEF, left ventricular ejection fraction; LVESVi, left ventricular end-systolic volume index; LVMi, left ventricular mass index; SVi, stroke volume index.