Uni- and multivariate Cox proportional hazard analyses for the identification of independent correlates of all-cause mortality
| Univariate analysis | Multivariate analysis | |||
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | |
| Age (per 1 year increase) | 1.05 (1.03 to 1.06) | <0.001 | 1.04 (1.02 to 1.05) | <0.001 |
| Male | 1.00 (0.81 to 1.22) | 0.973 | ||
| Previous MI (yes/no) | 1.72 (1.33 to 2.22) | <0.001 | ||
| eGFR <60 mL/min/1.73 m² (yes/no) | 2.55 (2.07 to 3.15) | <0.001 | 2.15 (1.71 to 2.70) | <0.001 |
| LV hypertrophy (yes/no) | 1.75 (1.39 to 2.20) | <0.001 | 1.67 (1.30 to 2.15) | <0.001 |
| LVEDV index (per 1 mL/m² increase) | 1.007 (1.003 to 1.011) | 0.001 | ||
| Moderate/severe MR (yes/no) | 1.50 (1.05 to 2.13) | 0.025 | ||
| Stroke volume index (per unit increase) | 0.986 (0.977 to 0.996) | 0.005 | ||
| TAPSE <1.7 cm (yes/no) | 1.71 (1.18 to 2.47) | 0.004 | ||
| Type of moderate AS | ||||
| Concordant moderate AS +LVEF≥50% | Reference | … | Reference | … |
| Discordant moderate AS +LVEF<50% | 3.11 (2.26 to 4.27) | <0.001 | 2.78 (2.00 to 3.87) | <0.001 |
| Discordant moderate AS +LVEF≥50% | 1.46 (1.06 to 2.01) | 0.022 | 1.01 (0.78 to 1.56) | 0.595 |
| Concordant moderate AS +LVEF<50% | 2.12 (1.49 to 3.01) | <0.001 | 1.58 (1.06 to 2.36) | 0.025 |
AS, aortic stenosis; eGFR, estimated glomerular filtration rate; LV, left ventricular; LVEDV, left ventricular end-diastolic volume; MI, myocardial infarction; MR, mitral regurgitation; TAPSE, tricuspid annular plane systolic excursion.