Echocardiographic characteristics at baseline
| Variable | Discordant moderate AS (N=150) | Concordant moderate AS (N=640) | P value |
| AVA (cm²) | 1.23±0.16 | 1.18±0.15 | <0.001 |
| Mean gradient (mmHg) | 15.7±3.1 | 28.5±6.4 | <0.001 |
| LV mass index (g/m²) | 125±35 | 120±36 | 0.093 |
| LV end-diastolic diameter (mm) | 52±7 | 48±7 | <0.001 |
| LV end-diastolic volume (mL) | 115±44 | 105±37 | 0.012 |
| LV end-systolic volume (mL) | 62±39 | 42±25 | <0.001 |
| LV end-diastolic volume index (mL/m²) | 70±29 | 61±21 | 0.003 |
| LV end-systolic volume index (mL/m²) | 37±24 | 25±15 | <0.001 |
| LV ejection fraction (%) | 49±16 | 61±10 | <0.001 |
| Stroke volume index (mL/m²) | 42±11 | 55±11 | <0.001 |
| Stroke volume index <35 mL/m² | 38 (26.6%) | 9 (1.5%) | <0.001 |
| LAVI (mL/m²) | 42.3±17.9 | 41.2±25.5 | 0.661 |
| E/e’ septal ratio | 21±10 | 17±8 | 0.002 |
| LV hypertrophy, n (%) | 105 (70.5%) | 387 (61.4%) | 0.040 |
| LVEF <50%, n (%) | 62 (41.3%) | 58 (9.1%) | <0.001 |
| Moderate/severe MR, n (%) | 22 (14.7%) | 42 (6.6%) | 0.001 |
| Moderate/severe TR, n (%) | 17 (11.3%) | 51 (8.0%) | 0.186 |
| TAPSE <1.7 cm, n (%) | 21 (14.2%) | 31 (5.0%) | <0.001 |
AVA, aortic valve area; LAVI, left atrial volume index; LV, left ventricle; LVEF, left ventricle ejection fraction; MR, mitral regurgitation; TAPSE, tricuspid annular plane systolic excursion; TR, tricuspid regurgitation.