Right-to-left shunt* | P value | ||

No (n=51) | Yes (n=8) | ||

RA | |||

RA volume max, mL/m^{2} | 59 (47.7–65.2) | 56.8 (50.3–64.4) | 0.965 |

RA volume min, mL/m^{2} | 27.7 (24.3–33.8) | 33.7 (28–35.2) | 0.241 |

RA expansion index, % | 98.5±29.5 | 81.9±15.9 | 0.030 |

RAA | |||

RAA volume max, mL/m^{2} | 17.1 (13.7–21.7) | 18.6 (16.1–24) | 0.341 |

RAA volume min, mL/m^{2} | 8.1 (6.3–10.1) | 10.3 (9.1–11.1) | 0.084 |

RAA expansion index, % | 105.6±24.1 | 84.7±18 | 0.022 |

LA | |||

LA volume max, mL/m^{2} | 44.3±7.9 | 46.5±5.1 | 0.452 |

LA volume min, mL/m^{2} | 17.5 (16.4–20.4) | 23.1 (19.4–24.2) | 0.019 |

LA expansion index, % | 140.1±33.7 | 109.8±18.6 | 0.017 |

LAA | |||

LAA volume max, mL/m^{2} | 7.2 (5.3–9.9) | 6 (3.8–7.3) | 0.535 |

LAA volume min, mL/m^{2} | 2.2 (1.3–3.7) | 2.9 (1.5–4.1) | 0.160 |

LAA expansion index, % | 229.1 (151.8–337.5) | 102.9 (65.6–121.7) | 0.002 |

Qp/Qs† | 0.98±0.07 | 0.91±0.06 | 0.027 |

Values are mean±SD or median (IQR). Expansion indices are calculated as (maximal volume–minimal volume) x 100%/minimal volume. P-values, see Statistics section for sensitivity analysis.

Statistically significant associations (P<0.05) denoted in bold.

*Shunt defined as moderate-to-severe and evaluated with transoesophageal echocardiography in patients (n=29) and transcranial Doppler in controls (n=30).

†One subject had missing data.

LA, left atrium; LAA, left atrial appendage; Qp/Qs, the ratio of total pulmonary to total systemic blood flow; RA, right atrium; RAA, right atrial appendage.