Baseline characteristics
| All sample (n=6237) | Women (n=2371) | Men (n=3866) | P value | |
| Demographics and medical history | ||||
| Age (years) | 65±11 | 68±11 | 63±12 | <0.001 |
| Diabetes, n (%) | 1786 (28.6) | 689 (29.1) | 1097 (28.4) | 0.562 |
| Hypertension, n (%) | 4079 (65.4) | 1624 (68.5) | 2455 (63.5) | <0.001 |
| Hypercholesterolaemia, n (%) | 3575 (57.3) | 1406 (59.3) | 2169 (56.1) | 0.013 |
| Current smoker, n (%) | 1139 (18.3) | 275 (11.6) | 864 (22.3) | <0.001 |
| Family history of IHD, n (%) | 323 (5.2) | 126 (5.3) | 197 (5.1) | 0.705 |
| Previous IHD, n (%) | 2357 (37.8) | 614 (25.9) | 1743 (45.1) | <0.001 |
| Previous MI, n (%) | 1164 (18.7) | 284 (12.0) | 880 (22.8) | <0.001 |
| Previous revascularisation, n (%) | 1481 (23.7) | 311 (13.1) | 1170 (30.3) | <0.001 |
| ECG | ||||
| ST-segment depression, n (%) | 189 (3.0) | 79 (3.3) | 110 (2.8) | 0.276 |
| T-wave inversion, n (%) | 471 (7.5) | 192 (8.1) | 279 (7.2) | 0.201 |
| LBBB, n (%) | 373 (6.0) | 187 (7.9) | 186 (4.8) | <0.001 |
| CMR indexes | ||||
| LVEF (%) | 62±13 | 66±12 | 60±14 | <0.001 |
| LVEDVI (ml/m2) | 73±26 | 67±22 | 76±27 | <0.001 |
| LVESVI (ml/m2) | 30±22 | 24±19 | 32±23 | <0.001 |
| Ischaemic burden, n (%) | <0.001 | |||
| ≤5 segments | 5231 (83.9) | 2092 (40.0) | 3139 (60.0) | |
| >5 segments | 1006 (16.1) | 279 (27.7) | 727 (72.3) | |
| LGE segments* | 0 (4) | 0 (3) | 1 (5) | <0.001 |
| Revascularisation procedures | ||||
| CMR-related revascularisation, n (%) | 583 (9.3) | 161 (6.8) | 422 (10.9) | <0.001 |
| CMR-related PCI, n (%) | 488 (7.2) | 125 (5.3) | 323 (8.3) | <0.001 |
| CMR-related CABG, n (%) | 143 (2.2) | 38 (1.6) | 105 (2.7) | 0.004 |
| Angiographic data | ||||
| Number of PD segments across number of diseased vessels*† | 0.444 | |||
| No coronary disease | 2 (4) | 2 (4) | 2 (4) | |
| 1 vessel | 4 (3.5) | 4 (4) | 4 (3) | |
| 2 vessels | 6 (4) | 6 (4) | 6 (5) | |
| 3 vessels | 7 (5) | 7 (5) | 7 (5) | |
Continuous values are expressed as mean±SD unless otherwise specified.
*Value expressed as median (IQR).
†Data available in 1066 patients.
CABG, coronary artery by-pass graft; CMR, cardiovascular magnetic resonance; IHD, ischaemic heart disease; LBBB, left bundle branch block; LGE, late gadolinium enhancement; LV, left ventricle; LVEDVI, left ventricle end-diastolic volume index; LVEF, left ventricular ejection fraction; LVESVI, left ventricle end-systolic volume index; MI, myocardial infarction; PCI, percutaneous coronary revascularisation; PD, perfusion deficit.