Table 3

Patient characteristics of the clinical event subgroups

	Event subgroups
	Thrombotic (n=3)			Major bleeding (n=2)		Minor bleeding (n=3)
	Patient 1	Patient 2	Patient 3	Patient 4	Patient 5	Patient 6	Patient 7	Patient 8
Age (years)	12.2	21.8	12.8	13.8	28.4	16.0	23.8	23.4
Gender	Male	Male	Male	Male	Male	Female	Male	Female
Primary diagnosis	DILV	PA-IVS	HLHS	DILV	CAVC	DILV	PA-IVS	DILV
Dominant Ventricle	Left	Left	Right	Left	Right	Left	Left	Left
Fontan type	ECC	ECC	ECC	ECC	ECC	LT	LT	LT
Years post-Fontan palliation	8.45	14.23	8.07	7.58	17.95	13.83	18.47	19.70
NYHA classification	1	1	2	1	3	1	2	1
Anticoagulant therapy	Aspirin	Rivaroxaban	Aspirin	Warfarin	Aspirin	Aspirin	Warfarin	Warfarin
Creatine (umol/L)	47	57	52	65	66	59	67	NA
DTPA GFR (mL/hour)	108	158	90	131	77	98.8	80	90
FibroScan (median KPA)	8.9	8.8	14.4	16.9	41.6	24.2	28.0	11.8
Liver panel (% of upper limit)
Total bilirubin (%)	100	93	6	133	48	24	233	167
AST (%)	72	85	68	118	46	6	58	55
ALT (%)	98	108	87	118	36	53	71	63
GGT (%)	82	92	69	65	100	73	151	24
ALP (%)	77	49	56	67	18	19	17	47
FibroTest score	0.48	0.66	0.39	0.47	NA	0.52	0.86	NA
MELD-XI score	38.07	49.83	9.44	9.44	9.44	49.83	49.83	NA
Clinical event	Systemic venous to atrium collateral occlusion	Stroke	Stroke	Mallory Weis tear	Haemoptysis (ICU admission)	Postoperative haematoma	Excessive bleeding post dental surery	Mouthbleeding

ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CAVC, complete atrioventricular canal defect; DILV, double inlet left ventricle; DTPA, diethylenetriamine pentaacetic acid; ECC, extracardiac conduit; GFR, glomerular filtration rate; GGT, gamma-glutamyl transferase; HLHS, hypoplastic leftheart syndrome; ICU, intensive care unit; LT, lateral tunnel; MELD-XI, model for end-stage liver disease excluding international normalised ratio; NA, not available; NYHA, New York Heart Association; PA-IVS, pulmonary atresia with intact ventricular septum.