Comparison of thrombin generation, surrogate platelet activity and hepatic dysfunction outcome between the thrombotic-events group and the major-bleeding and minor-bleeding group
| Thrombing generation | Thrombotic (n=3) | Major bleeding (n=2) | Minor bleeding (n=3) | ||
| Mean (SD) | Mean (SD) | P value | Mean (SD) | P value | |
| ETP | 1366.4 (±66.2) | 1011.06 (±138.44) | 0.027 | 1218.25 (±74.33) | 0.061 |
| Lag time | 2.21 (±0.56) | 2.5 (±0.00) | 1* | 2.35 (±0.25) | 0.817* |
| Peak | 356.39 (±21.36) | 252.86 (±90.91) | 0.083* | 321.81 (±55.06) | 0.513* |
| Time to peak | 4.2 (±0.56) | 4.75 (±0.35) | 0.374* | 4.41 (±0.32) | 0.658* |
| Velocity index | 178.33 (±10.58) | 117 (±58.79) | 0.375 | 158.06 (±32.50) | 0.362 |
| Start of tail | 19.03 (±1.07) | 19.54 (±2.42) | 1* | 19.18 (±2.48) | 0.827* |
| Alpha-2 level | 14.34 (±2.19) | 8.91 (±4.11) | 0.083* | 19.84 (±5.63) | 0.275* |
| Platelet activity markers | |||||
| P-selectin level | 31.77 (±9.34) | 32.642 (±4.624) | 1* | 29.912 (±5.699) | 0.513* |
| PF4 level | 264 (±153.1) | 130.115 (±0) | 0.221* | 351.351 (±312.875) | 1* |
| Hepatic dysfunction | |||||
| Fibro-scan | 10.7 (±3.2) | 29.3 (±17.5) | 0.083* | 21.3 (±8.5) | 0.127* |
| MELD-XI score | 1.5 (±1.60) | 10.05 (±4.74) | 0.218 | 9.23 | 0.011 |
| MELD-XI score | 1.5 (±1.60) | 10.05 (±4.74) | 0.218 | 9.23 | 0.011 |
*Differences between groups were anaylysed using an independent-samples t-test. If the normality assumption was severely violated, a Mann-Whitney U test was used. Values marked by an asterisk were analysed by use of the Mann-Whitney U test.
ETP, endogenous thrombin potential; MELD-XI, model for end-stage liver disease excluding international normalised ratio; PF4, platelet factor 4.