Table 4

Comparison of thrombin generation, surrogate platelet activity and hepatic dysfunction outcome between the no-events group and the thrombotic, major bleeding and minor bleeding group

Thrombing generation	No-events (n=62)	Thrombotic (n=3)		Major bleeding (n=2)		Minor bleeding (n=3)
Thrombing generation	Mean (SD)	Mean (SD)	P value	Mean (SD)	P value	Mean (SD)	P value
ETP	1230.6 (±374.6)	1366.4 (±66.2)	0.536	1011.06 (±138.44)	0.415	1218.25 (±74.33)	0.955
Lag time	2.35 (±0.55)	2.21 (±0.56)	0.987*	2.5 (±0.00)	0.409*	2.35 (±0.25)	0.6*
Peak	305.5 (±102.2)	356.39 (±21.36)	0.365*	252.86 (±90.91)	0.354*	321.81 (±55.06)	0.925*
Time to peak	4.39 (±0.68)	4.2 (±0.56)	0.862*	4.75 (±0.35)	0.228*	4.41 (±0.32)	0.539*
Velocity index	156.2 (±61.31)	178.33 (±10.58)	0.044	117 (±58.79)	0.377	158.06 (±32.50)	0.959
Start of tail	19.74 (±2.72)	19.03 (±1.07)	0.876*	19.54 (±2.42)	0.877*	19.18 (±2.48)	0.815*
Alpha-2 level	13.31 (±6.01)	14.34 (±2.19)	0.532*	8.91 (±4.11)	0.280*	19.84 (±5.63)	0.07*
Platelet activity markers
P-selectin level	36.56 (±9.99)	31.77 (±9.34)	0.535*	32.642 (±4.624)	0.596*	29.912 (±5.699)	0.28*
PF4 level	280.65 (±146.76)	264 (±153.1)	0.983*	130.115 (±0)	0.18*	351.351 (±312.875)	0.907*
Hepatic dysfunction
Fibro-scan	16.9 (±7.6)	10.7 (±3.2)	0.067*	29.3 (±17.5)	0.194*	21.3 (±8.5)	0.262*
Fibro-test score	0.482 (±0.199)	0.513 (±0.137)	0.789	0.471 (±0)	0.96	0.692 (±0.24)	0.15
MELD-XI score	3.31 (±4.68)	1.5 (±1.60)	0.508	10.05 (±4.74)	0.05	9.23 (±2.52)	0.034

*Differences between groups were anaylysed using an independent-samples t-test. If the normality assumption was severely violated, a Mann-Whitney U test was used. Values marked by an asterisk were analysed by use of the Mann-Whitney U test.
ETP, endogenous thrombin potential; MELD-XI, model for end-stage liver disease excluding international normalised ratio; PF4, platelet factor 4.