Demographic, clinical and angiographic characteristics of STEMI patients
| Total cohort | Group 1 | Group 2 | Group 3 | Group 4 | P value | |
| 0 hour<S2C≤24 hours | S2C≤1 hour | 1 hour<S2C≤2 hours | 2 hours<S2C≤6 hours | 6 hours<S2C≤24 hours | ||
| (n=20 005) | (n=9301) | (n=4170) | (n=4193) | (n=2341) | ||
| Demographic data | ||||||
| Male gender | 14 721 (74%) | 7180 (77%) | 3007 (72%) | 2943 (70%) | 1591 (68%) | <0.0001 |
| Age±SD (years) | 63.8±12.8 | 62.5±12.7 | 64.1±12.9 | 65.3±12.9 | 65.5±12.5 | <0.0001 |
| Age >80 years | 2171 (11%) | 866 (9%) | 478 (11%) | 544 (13%) | 283 (12%) | <0.0001 |
| Clinical data | ||||||
| Body mass index (kg/m²) | 27.5±4.6 | 27.5±4.4 | 27.6±4.7 | 27.6±4.6 | 27.6±4.8 | 0.142 |
| Hypertension | 11 897 (59%) | 5332 (57%) | 2522 (60%) | 2595 (62%) | 1448 (62%) | <0.0001 |
| Diabetes mellitus | 3486 (17%) | 1420 (15%) | 764 (18%) | 811 (19%) | 491 (21%) | <0.0001 |
| Prior angina pectoris | 2432 (12%) | 966 (10%) | 529 (13%) | 560 (13%) | 377 (16%) | <0.0001 |
| Hyperlipidaemia | 5825 (29%) | 2671 (29%) | 1.212 (29%) | 1281 (31%) | 661 (28%) | 0.1226 |
| Family history | 3799 (19%) | 1753 (19%) | 814 (19%) | 791 (19%) | 441 (18%) | 0.8195 |
| Current smoker | 8433 (42%) | 4082 (44%) | 1792 (43%) | 1665 (40%) | 894 (38%) | <0.0001 |
| Previous MI | 2216 (11%) | 1136 (12%) | 487 (12%) | 389 (9%) | 204 (9%) | <0.0001 |
| Previous stroke | 823 (4%) | 391 (4%) | 184 (4%) | 166 (4%) | 82 (4%) | 0.3108 |
| Previous angioplasty | 2325 (12%) | 1191 (13%) | 522 (13%) | 411 (10%) | 201 (9%) | <0.0001 |
| Previous CABG | 422 (2%) | 175 (2%) | 97 (2%) | 97 (2%) | 53 (2%) | 0.2218 |
| Renal failure | 956 (5%) | 434 (5%) | 175 (4%) | 213 (5%) | 134 (6%) | 0.0336 |
| ECG (STEMI site) | 0.0003 | |||||
| Anterior | 8835 (44%) | 4256 (46%) | 1773 (42%) | 1743 (42%) | 1063 (45%) | |
| Inferior | 9930 (50%) | 4468 (48%) | 2155 (52%) | 2181 (52%) | 1126 (48%) | |
| Lateral | 1051 (5%) | 485 (5%) | 210 (5%) | 228 (5%) | 128 (5%) | |
| LBBB | 189 (1%) | 89 (1%) | 35 (1%) | 41 (1%) | 24 (1%) | |
| TIMI risk score | ||||||
| 0–2 | 7.011 (35%) | 3525 (38%) | 1640 (39%) | 1313 (31%) | 533 (23%) | <0.0001 |
| 3–4 | 5782 (29%) | 2622 (28%) | 1272 (30%) | 1233 (29%) | 655 (28%) | |
| 5–8 | 6255 (31%) | 2714 (29%) | 1126 (27%) | 1442 (34%) | 973 (42%) | |
| >8 | 965 (5%) | 443 (5%) | 136 (3%) | 206 (5%) | 180 (8%) | |
| Cardiogenic shock | 2423 (12%) | 1646 (18%) | 309 (7%) | 299 (7%) | 169 (7%) | <0.0001 |
| OHCA | 1881 (9%) | 1474 (16%) | 171 (4%) | 156 (4%) | 80 (3%) | <0.0001 |
| Procedural data | ||||||
| Time of EMS at scene (min) | 23.4±11.8 | 24.1±12.7 | 21.3±10.5 | 21.1±10.8 | 20.2±10.7 | <0.0001 |
| Transportation time (min) | 17.0±10.7 | 17.0±10.6 | 17.2±10.7 | 17.1±10.3 | 16.7±11.6 | 0.222 |
| Contact-to-door time (min) | 39.5±16.2 | 41.1±16.8 | 38.5±15.4 | 38.2±15.3 | 37.0±15.9 | <0.0001 |
| Door-to-cath. lab. time (min) | 24.1±33.1 | 23.4±31.0 | 23.0±31.5 | 24.8±35.1 | 27.3±39.2 | <0.0001 |
| Cath. lab.-to-puncture (min) | 12.0±7.1 | 12.2±7.3 | 11.9±6.7 | 11.7±6.8 | 11.9±7.1 | 0.0002 |
| Puncture-to-balloon (min) | 20.4±12.6 | 20.1±12.7 | 20.2±12.2 | 20.5±12.0 | 21.6±14.2 | <0.0001 |
| Door-to-balloon time (min) | 56.5±37.6 | 55.7±35.6 | 55.1±35.9 | 57.0±39.4 | 60.8±44.0 | <0.0001 |
| Contact-to-balloon (min) | 95.9±41.3 | 96.8±39.9 | 93.6±39.6 | 95.3±42.2 | 97.7±47.3 | <0.0001 |
| Direct transfer to cath. lab. (%) | 11 022 (55%) | 5076 (55%) | 2332 (56%) | 2345 (56%) | 1269 (54%) | 0.264 |
| Angiographic data | ||||||
| No of coronary arteries narrowed | ||||||
| 0 | 60 (0.3%) | 26 (0.3%) | 11 (0.3%) | 17 (0.4%) | 6 (0.3%) | <0.0001 |
| 1 | 7761 (39%) | 3788 (41%) | 1612 (39%) | 1531 (37%) | 830 (35%) | |
| 2 | 6230 (31%) | 2800 (30%) | 1336 (32%) | 1337 (32%) | 757 (32%) | |
| 3 | 5831 (29%) | 2617 (28%) | 1191 (29%) | 1287 (31%) | 736 (31%) | |
| LMCA | 130 (0.7%) | 72 (0.8%) | 124 (0.6%) | 22 (0.5%) | 12 (0.5%) | |
| CTO in NIRA | 2293 (12%) | 1027 (12%) | 462 (12%) | 491 (13%) | 313 (15%) | 0.0078 |
| STEMI recanalisation vessel | 0.0004 | |||||
| LAD | 8787 (44%) | 4209 (45%) | 1794 (43%) | 1742 (42%) | 1042 (45%) | |
| RCA | 8265 (41%) | 3743 (40%) | 1782 (43%) | 1800 (43%) | 940 (40%) | |
| LCX | 2575 (13%) | 1168 (13%) | 530 (13%) | 568 (14%) | 309 (13%) | |
| LMCA | 207 (1%) | 114 (1%) | 29 (1%) | 43 (6%) | 21 (3%) | |
| Graft | 177 (1%) | 68 (1%) | 39 (1%) | 41 (1%) | 29 (1%) | |
| TIMI angiographic flow grade before PCI | ||||||
| Score 0–2 | 18 488 (92%) | 8549 (92%) | 3839 (92%) | 3893 (93%) | 2207 (94%) | |
| Score 3 | 1523 (8%) | 753 (8%) | 335 (8%) | 301 (7%) | 134 (6%) | 0.0007 |
| TIMI angiographic flow grade after PCI | ||||||
| Score 0–2 | 1306 (7%) | 533 (6%) | 251 (6%) | 3894 (7%) | 222 (9%) | |
| Score 3 | 18 705 (93%) | 8769 (94%) | 3923 (94%) | 569 (93%) | 2119 (91%) | <0.0001 |
| Treatment and outcome | ||||||
| IABP | 278 (1.4%) | 178 (1.9%) | 34 (0.8%) | 43 (1.0%) | 23 (1.0%) | <0.0001 |
| In-hospital mortality | 1554 (7.8%) | 928 (10.0%) | 205 (4.9%) | 251 (6.0%) | 170 (7.3%) | <0.0001 |
Data are presented as means and SD or percentages.
*P values refer to the comparisons between the four groups.
.CABG, coronary artery bypass grafting; CTO, chronic total occlusion; ECMO, extracorporeal membrane oxygenation; EMS, emergency medical service; IABP, intra-aortic balloon pump; cath. lab, catheterisation laboratory; LBBB, left bundle branch block; LCA, left coronary artery; LCX, left circumflex artery; LMCA, left main coronary artery; MI, myocardial infarction; NIRA, non-infarct-related arteries; OHCA, out-of-hospital cardiac arrest; RCA, right coronary artery; TIMI, Thrombolysis In Myocardial Infarction score.