Table 2

Relationships between cardiovascular risk factors and incidence of non-fatal and fatal first-time coronary events and the significance of difference between the two outcomes

	Non-fatal coronary event			Fatal coronary event			Heterogeneity
	HR	95% CI	P value	HR	95% CI	P value	P value
Model 1
Age, year	1.07	1.07 to 1.08	<0.001	1.12	1.11 to 1.13	<0.001	<0.0001
Male gender	2.54	2.33 to 2.76	<0.001	4.06	3.51 to 4.69	<0.001	<0.0001
Diabetes	2.35	2.15 to 2.57	<0.001	2.52	2.20 to 2.89	<0.001	0.57
Current smoking	1.88	1.77 to 2.01	<0.001	2.48	2.24 to 2.76	<0.001	<0.0001
Cholesterol, per mmol/L	1.32	1.29 to 1.36	<0.001	1.33	1.27 to 1.39	<0.001	0.86
Body mass index, per kg/m²	1.25	1.19 to 1.31	<0.001	1.43	1.32 to 1.54	<0.001	0.0031
Systolic blood pressure, per 10 mm Hg	1.14	1.12 to 1.16	<0.001	1.22	1.19 to 1.25	<0.001	0.0001
Diastolic blood pressure, per 10 mm Hg	1.20	1.16 to 1.24	<0.001	1.34	1.28 to 1.41	<0.001	0.0001
Antihypertensive treatment	1.55	1.38 to 1.75	<0.001	1.77	1.49 to 2.10	<0.001	0.23
Model 2
Age, per year	1.06	1.06 to 1.07	<0.001	1.11	1.10 to 1.12	<0.001	<0.0001
Male gender	2.30	2.11 to 2.50	<0.001	3.52	3.03 to 4.08	<0.001	<0.0001
Diabetes	1.94	1.70 to 2.21	<0.001	1.90	1.56 to 2.32	<0.001	0.867
Current smoking	1.93	1.81 to 2.05	<0.001	2.68	2.41 to 2.98	<0.001	<0.0001
Cholesterol, per mmol/L	1.26	1.23 to 1.29	<0.001	1.24	1.18 to 1.29	<0.001	0.473
Body mass index, per kg/m²	1.14	1.08 to 1.19	<0.001	1.28	1.19 to 1.39	<0.001	0.011
Systolic blood pressure, per 10 mm Hg	1.11	1.09 to 1.13	<0.001	1.19	1.15 to 1.23	<0.001	0.0002
Diastolic blood pressure, per 10 mm Hg	1.16	1.12 to 1.20	<0.001	1.29	1.23 to 1.36	<0.001	0.0007
Antihypertensive treatment	1.32	1.17 to 1.50	<0.001	1.37	1.15 to 1.64	0.001	0.659

Model 1 includes covariates age and gender.
Model 2 includes age, gender, body mass index, diabetes, smoking habits, cholesterol, either systolic blood or diastolic blood pressure and antihypertensive treatment. Note: when systolic and diastolic blood pressure were included in the same model, systolic blood pressure showed stronger relationships to both non-fatal and fatal coronary events, compared with diastolic blood pressure.