Table 3

Relationships between haemodynamic parameters and incidence of non-fatal and fatal first-time coronary events and the significance of difference between the two different outcomes

Non-fatal coronary eventFatal coronary eventHeterogeneity
HR95% CIP valueHR95% CIP valueP value
Orthostatic hypotension
 Model 11.291.14 to 1.45<0.0011.321.10 to 1.580.0030.84
 Model 21.090.96 to 1.230.1801.020.84 to 1.230.8600.56
∆SBP per −10∆mm Hg
 Model 11.101.06 to 1.14<0.0011.071.01 to 1.140.0150.52
 Model 21.031.00 to 1.070.0840.970.92 to 1.030.3640.089
∆DBP per −10∆mm Hg
 Model 11.161.09 to 1.23<0.0011.101.00 to 1.210.0410.37
 Model 2*1.061.00 to 1.130.0580.950.86 to 1.040.2750.052
PP per 10 mm Hg
 Model 11.131.10 to 1.17<0.0011.221.17 to 1.27<0.0010.007
 Model 2†1.101.07 to 1.13<0.0011.181.13 to 1.23<0.0010.013
RHR per 10 bpm
 Model 11.071.03 to 1.10<0.0011.221.17 to 1.28<0.001<0.0001
 Model 20.980.95 to 1.010.1811.091.04 to 1.150.0010.0004
  • Model 1 includes covariates age and gender.

  • Model 2 includes age, gender, diabetes, smoking habits, cholesterol, body mass index, antihypertensive treatment and systolic blood pressure.

  • *Adjusted for diastolic instead of systolic blood pressure.

  • †Not adjusted for systolic or diastolic blood pressure.

  • bpm, beats per minute; DBP, diastolic blood pressure; PP, pulse pressure; RHR, resting heart rate at baseline; SBP, systolic blood pressure.