Temporal changes in coagulation assays over time
| Variable | T0 | T1 | T2 | T3 |
| Laboratory | ||||
| PT | ||||
| Median (IQR) | 13 (12–14) | 22 (20–26) | 13 (13–15) | 12 (12–13) |
| P value | – | 0.003 | 0.415 | 0.191 |
| APTT | ||||
| Median (IQR) | 27 (26–32) | 180 (180–180) | 28 (28–31) | 27 (26–31) |
| P value | – | 0.001 | 0.870 | 0.976 |
| TCT | ||||
| Median (IQR) | 16 (14–18) | 180 (180–180) | 17 (16–24) | 15 (14–17) |
| P value | – | 0.020 | 0.054 | 0.256 |
| Fibrinogen | ||||
| Median (IQR) | 2.87 (2.61–3.01) | 2.65 (2.19–2.78) | 2.69 (2.65–2.91) | 3.16 (2.91–3.37) |
| P value | – | 0.016 | 0.858 | 0.007 |
| ROTEMSigma | ||||
| MCF FIBTEM | ||||
| Median (IQR) | 18 (12–19) | 15 (12–19) | 17 (13–18) | 17 (12–20) |
| P value | – | 0.299 | 0.494 | 0.928 |
| CT HEPTEM | ||||
| Median (IQR) | 178 (169–181) | 223 (212–229) | 181 (175–187) | 177 (162–183) |
| P value | – | 0.004 | 0.126 | 0.755 |
| MCF HEPTEM | ||||
| Median (IQR) | 60 (52–66) | 60 (58–66) | 58 (57–59) | 61 (58–63) |
| P value | – | 0.211 | 0.878 | 0.097 |
| TEG6s | ||||
| MA CRT | ||||
| Mean (SD) | 63.2 (3.3) | 64.3 (2.6) | 63.6 (2.9) | 63.8 (2.9) |
| P value | 0.005 | 0.272 | 0.164 | |
| R CRT | ||||
| Mean (SD) | 0.44 (0.13) | 2.27 (1.00) | 0.59 (0.24) | 0.40 (0.13) |
| P value | <0.001 | 0.057 | 0.459 | |
| MA CKH | ||||
| Median (IQR) | 60.9 (58.2–63.5) | 60.8 (33.1–62.0) | 60.7 (57.3–61.2) | 62.0 (59.2–66.1) |
| P value | – | 0.500 | 0.998 | 0.018 |
| R CKH | ||||
| Median (IQR) | 7.2 (6.9–8.0) | 9.8 (6.1–12.3) | 8.9 (7.1–9.5) | 8.1 (7.2–8.8) |
| P value | – | 0.286 | 0.083 | 0.062 |
| MA CFF | ||||
| Median (IQR) | 23.6 (20.5–26.6) | 22.1 (19.2–24.9) | 23.5 (21.1–26.5) | 22.9 (20.3–29.6) |
| P value | – | 0.655 | 0.306 | 0.247 |
| TEG-ACT | ||||
| Median (IQR) | 97 (79–97) | 219 (182–303) | 97 (88–116) | 88 (79–97) |
| P value | – | 0.003 | 0.058 | 0.582 |
aPTT, activated partial thromboplastin time; CFF, citrated functional fibrinogen; CK, citrated kaolin; CKH, citrated kaolin with heparinase; CRT, RapidTEG; CT, clotting time; EXTEM, activation of extrinsic pathway; FIBTEM, activation of extrinsic pathway and in vitro blocking of thrombocytes; HEPTEM, activation of intrinsic pathway and in vitro blocking of heparin; INTEM, activation of intrinsic pathway; MA, maximum amplitude; MCF, maximum clot firmness; PT, prothrombin time; R, reaction time; T0, baseline post induction of anaesthesia; T1, postheparin and TAVI deployment; T2, post protamine; T3, 6 hours postprocedure; TCT, total clotting time.