Table 3

C-indices with 95% CI for the ABC-AF-bleeding risk score in ARISTOTLE and RE-LY comparing geographic regions

C-index95% CIC-index95% CI
Major bleeding
 All0.6770.657 to 0.6980.7080.684 to 0.731
 Asia/Pacific0.6840.639 to 0.7280.6490.558 to 0.739
 Europe0.6800.641 to 0.7190.7010.664 to 0.739
 Latin America0.6740.629 to 0.7190.6570.561 to 0.754
 North America0.6590.620 to 0.6990.7100.672 to 0.749
 Other0.7600.698 to 0.822
  • ABC-AF bleeding score, Age, Biomarkers (troponin T-hs, haemoglobin, and GDF-15), Clinical history (previous bleeding); ARISTOTLE, Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation; RE-LY, Randomized Evaluation of Long-Term Anticoagulation Therapy.