Patient demographics
| Mean±SD or number (%) | Left ventricular diastolic function | All | ||
| Normal | Abnormal | Indeterminate | ||
| Age (years) | 56±12 | 65±11* | 59±14 | 59±13 |
| Female | 21 (50%) | 12 (60%) | 5 (50%) | 38 (53%) |
| Blood pressure (mm Hg) | ||||
| Systolic | 128±13 | 131±9 | 122±9 | 128±12 |
| Diastolic | 76±9 | 76±6 | 73±7 | 76±9 |
| Heart rate (beats/min) | ||||
| CTCA | 56±6† | 57±7† | 58±4† | 56±6† |
| TTE | 71±12 | 69±11 | 69±9 | 70±11 |
| Risk factors for CAD | ||||
| Family history | 34 (81%) | 17 (85%) | 8 (80%) | 59 (82%) |
| Hypertension | 23 (55%) | 15 (75%) | 5 (50%) | 43 (60%) |
| Type II diabetes | 5 (12%) | 7 (35%) | 0 | 12 (17%) |
| Active smoking | 7 (17%) | 4 (20%) | 0 | 11 (15%) |
| Hyperlipidaemia | 28 (67%) | 17 (85%) | 8 (80%) | 53 (74%) |
| Total cholesterol (mmol/L) | 4.9±0 .8 | 5.2±1.1 | 5.9±1.8 | 5.1±1.1 |
| HDL level (mmol/L) | 1.3±0.4 | 1.5±0.4 | 1.4±0.4 | 1.4±0.4 |
| LDL level (mmol/L) | 2.8±0 .9 | 3.0±0 .9 | 2.9±1.0 | 2.9±1.0 |
| Body surface area (m2) | 1.93±0.25 | 1.93±0.29 | 1.74±0.22 | 1.90±0.27 |
| Presence of CAD | ||||
| Normal to minimal | 20 (48%) | 11 (55%) | 6 (60%) | 34 (47%) |
| Mild disease | 20 (48%) | 4 (20%) | 3 (30%) | 30 (42%) |
| Moderate and/or severe | 2 (5%) | 5 (25%)* | 1 (10%) | 8 (11%) |
| Medications | ||||
| Calcium channel blockers | 5 (12%) | 4 (20%) | 1 (10%) | 10 (14%) |
| Beta blockers | 9 (21%) | 3 (15%) | 4 (40%) | 16 (22%) |
| ACE inhibitors or angiotensin II | 10 (24%) | 11 (55%) | 3 (30%) | 24 (33%) |
| Diuretics (thiazides or aldosterone antagonists)† | 5 (12%) | 4 (20%) | 0 | 9 (13%) |
| Vasodilators (alpha-blockers or nitrates) | 1 (2%) | 2 (10%) | 0 | 3 (4%) |
| Statins | 17 (40%) | 12 (60%) | 5 (50%) | 34 (47%) |
| Oral diabetic medications | 2 (5%) | 2 (10%) | 0 | 4 (6%) |
*P<0.05 (abnormal vs normal diastolic left ventricular function).
†P<0.05 (CTCA vs TTE corresponding data). None of the patients were on loop diuretics, and/or SGLT-2 inhibitors.
CAD, coronary artery disease; CTCA, CT coronary angiography; HDL, high density lipoprotein; LDL, low density lipoprotein; TTE, transthoracic echocardiogram.