Clinical characteristics in categorised groups by LV and PV reserve
Norma LV and PV reserve | Impaired PV and normal LV reserve | Impaired LV and normal PV reserve | Impaired LV and PV reserve | |
Number | 49 | 36 | 27 | 28 |
Age | 57±12 | 61±12 | 64±10 | 63±11 |
Male, % | 5 (10) | 6 (17) | 1 (4) | 2 (7) |
Rest echocardiographic variables | ||||
LVEDVi, mL/m2 | 50±10 | 50±14 | 48±11 | 48±9 |
LVESVi, mL/m2 | 17±4 | 17±5 | 17±4 | 17±4 |
LVEF, % | 65±4 | 66±3 | 64±3 | 66±4 |
LVMi, g/m2 | 76±17 | 76±15 | 74±20 | 74±15 |
LAVi, mL/m2 | 27±8 | 27±10 | 32±7 | 29±11 |
e’, cm/s | 11±3 | 11±3 | 10±2 | 10±3 |
E/e' | 6±2 | 8±3 | 8±4 | 7±3 |
RVEDA, cm2 | 14±3 | 15±4 | 14±3 | 14±3 |
RVESA, cm2 | 8±2 | 8±2 | 8±2 | 8±2 |
RVFAC, % | 44±11 | 46±9 | 43±10 | 44±10 |
GLS, % | 19±2 | 19±4 | 19±2 | 19±3 |
RVLS, % | 24±5 | 26±6 | 24±7 | 25±7 |
Exercise haemodynamics | ||||
Mean PAP, mm Hg | 17±2 | 17±4 | 18±2 | 18±3 |
Mean PAWP, mm Hg | 10±2 | 11±5 | 12±4 | 11±4 |
CO, L/min | 3.9±1.1 | 3.9±1.6 | 3.7±1.0 | 3.7±0.9 |
PVR, wood unit | 1.9±0.9 | 1.8±0.9 | 1.8±0.8 | 2.4±1.8 |
Exercise mean PAP, mm Hg | 21±4 | 24±5* | 21±3 | 26±6* |
Exercise mean PAWP, mm Hg | 11±3 | 12±5 | 15±4* | 14±5* |
Exercise CO, L/min | 7.3±2.5 | 5.5±1.7* | 5.8±1.8* | 4.9±0.9* |
Exercise PVR, wood unit | 1.6±0.6 | 2.4±0.8* | 1.3±0.6 | 2.7±1.4* |
ΔmPAP/ΔCO, mm Hg/L/min | 1.6±0.7 | 5.0±2.0* | 1.8±0.7 | 9.5±6.0* |
ΔmPAWP/ΔCO, mm Hg/L/min | 0.3±0.2 | 0.7±0.4 | 1.5±0.5* | 3.0±1.7* |
HR for outcomes | Reference | 9.9 (1.2–83.1)* | 8.4 (1.1–72.8)* | 35.4 (4.6–271)* |
*Versus normal LV and PV, p<0.05.
CO, cardiac output; e’, early diastolic mitral annular motion; E, early diastolic transmitral flow velocity; LAVi, left atrial volume index; LVEDVi, left ventricular end-diastolic volume index; LVEF, left ventricular ejection fraction; LVESVi, left ventricular end-systolic volume index; LVMi, left ventricular mass index; mPAP, mean pulmonary artery pressure; mPAWP, mean pulmonary artery wedge pressure; PVR, pulmonary vascular resistance; RVEA, right ventricular end-diastolic area; RVESA, right ventricular end-systolic area; RVFAC, right ventricular functional area change; TAPSE, tricuspid annular plane systolic excursion.