Table 3

Univariate associations of outcomes

Univariate model
HR95% CIP value
Age1.020.98 to 1.050.54
Male, %0.410.01 to 9.170.25
Disease duration0.990.99 to 1.010.75
HR, bpm1.000.97 to 1.040.87
Systolic BP, mm Hg0.990.98 to 1.020.72
SpO2, %0.930.73 to 1.190.57
Rest echocardiographic variables
LVEF, %1.010.95 to 1.070.86
LAVi, mL/m21.010.97 to 1.050.73
E/e'1.091.01 to 1.190.04
GLS0.880.71 to 1.100.26
RVLS0.970.87 to 1.090.67
Exercise haemodynamics
mPAP, mm Hg1.090.95 to 1.260.22
mPAWP, mm Hg1.071.00 to 1.150.04
CO, L/min1.140.84 to 1.550.41
Exercise mPAP, mm Hg1.061.00 to 1.130.07
Exercise mPAWP, mm Hg1.081.02 to 1.150.012
Exercise CO, L/min0.840.66 to 1.060.14
ΔmPAWP1.271.01 to 1.610.049
ΔCO0.580.38 to 0.870.009
ΔmPAP/ΔCO, mm Hg/L/min1.061.02 to 1.100.002
ΔmPAWP/ΔCO, mm Hg/L/min1.381.17 to 1.63<0.001
Δe’, cm/s0.950.84 to 1.070.38
  • BP, blood pressure; CO, cardiac output; %DLCO, diffusing capacity for carbon monoxide; e’, early diastolic mitral annular motion; E, early diastolic transmitral flow velocity; %FEV1, percent forced expiratory volume in 1 s; %FVC, percent forced vital capacity; HR, heart rate; LAVi, left atrial volume index; LVEDVi, left ventricular end-diastolic volume index; LVEF, left ventricular ejection fraction; LVESVi, left ventricular end-systolic volume index; LVMi, left ventricular mass index; MCTD, mixed connective tissue disease; mPAP, mean pulmonary artery pressure; mPAWP, mean pulmonary artery wedge pressure; PVR, pulmonary vascular resistance; RVEA, right ventricular end-diastolic area; RVESA, right ventricular end-systolic area; RVFAC, right ventricular functional area change; SpO2, percutaneous oxygen saturation; SSc, systemic sclerosis; TAPSE, tricuspid annular plane systolic excursion.