Univariable | Multivariable | |||
HR (95% CI) | P value | HR (95% CI) | P value | |
(A) V-FMR | ||||
Age, 1 year | 1.019 (1.007 to 1.030) | 0.001 | 1.024 (1.012 to 1.036) | <0.001 |
Male sex | 1.175 (0.854 to 1.616) | 0.32 | ||
NYHA functional class III/IV | 1.173 (0.840 to 1.638) | 0.35 | ||
Atrial fibrillation | 1.468 (1.092 to 1.973) | 0.011 | ||
Systolic blood pressure, 1 mm Hg | 0.995 (0.988 to 1.002) | 0.17 | 0.991 (0.983 to 0.999) | 0.028 |
Log B-type natriuretic peptide, 1 pg/mL | 1.361 (1.191 to 1.554) | <0.001 | 1.325 (1.154 to 1.523) | <0.001 |
Estimated glomerular filtration rate, 1 mL/min/1.73 m2 | 0.989 (0.982 to 0.995) | 0.001 | ||
LV end-systolic dimension, 1 mm | 1.004 (0.992 to 1.016) | 0.54 | ||
LV ejection fraction, 1% | 0.989 (0.975 to 1.003) | 0.12 | ||
LA volume index, 1 mL/m2 | 1.005 (1.002 to 1.008) | <0.001 | 1.004 (1.001 to 1.007) | 0.008 |
Tricuspid regurgitation | 0.955 (0.579 to 1.574) | 0.86 | ||
MR regurgitant volume, 1 mL | 1.011 (0.996 to 1.028) | 0.16 | ||
(B) A-FMR | ||||
Age, 1 year | 1.057 (1.015 to 1.101) | 0.008 | 1.056 (1.002 to 1.114) | 0.043 |
Male sex | 0.972 (0.512 to 1.846) | 0.93 | ||
NYHA functional class III/IV | 2.864 (0.688 to 7.993) | 0.13 | ||
Atrial fibrillation | 1.821 (0.561 to 5.907) | 0.32 | ||
Systolic blood pressure, 1 mm Hg | 0.993 (0.975 to 1.011) | 0.44 | ||
Log B-type natriuretic peptide, 1 pg/mL | 1.837 (1.234 to 2.735) | 0.003 | ||
Estimated glomerular filtration rate, 1 mL/min/1.73 m2 | 0.963 (0.947 to 0.979) | <0.001 | 0.979 (0.961 to 0.997) | 0.025 |
LV end-systolic dimension, 1 mm | 1.057 (1.006 to 1.110) | 0.027 | 1.082 (1.022 to 1.145) | 0.007 |
LV ejection fraction, 1% | 0.964 (0.922 to 1.008) | 0.11 | ||
LA volume index, 1 mL/m2 | 1.006 (1.003 to 1.010) | <0.001 | 1.005 (1.001 to 1.008) | 0.022 |
Tricuspid regurgitation | 1.990 (1.067 to 3.709) | 0.030 | 2.389 (1.185 to 4.816) | 0.015 |
MR regurgitant volume, 1 mL | 1.018 (0.985 to 1.053) | 0.29 |
LA, left atrium; LV, left ventricle; MR, mitral regurgitation; NYHA, New York Heart Association.