Table 4

Multivariable Cox regression hazard analysis for risk of the composite end point

	Univariable		Multivariable
	HR (95% CI)	P value	HR (95% CI)	P value
V-FMR/A-FMR	1.762 (1.250 to 2.438)	<0.001	1.654 (1.027 to 2.664)	0.038
Age, 1 year	1.015 (1.005 to 1.026)	0.004	1.027 (1.015 to 1.040)	<0.001
Male sex	1.255 (0.953 to 1.654)	0.11
NYHA functional class III/IV	1.394 (1.016 to 1.912)	0.039
Atrial fibrillation	1.161 (0.888 to 1.517)	0.28	1.437 (1.046 to 1.973)	0.025
Systolic blood pressure, 1 mm Hg	0.992 (0.985 to 0.998)	0.015
Log B-type natriuretic peptide, 1 pg/mL	1.453 (1.289 to 1.637)	<0.001	1.332 (1.162 to 1.526)	<0.001
Estimated glomerular filtration rate, 1 mL/min/1.73 m²	0.985 (0.978 to 0.991)	<0.001
LV end-systolic dimension, 1 mm	1.014 (1.005 to 1.023)	0.002	1.017 (1.002 to 1.031)	0.025
LV ejection fraction, 1%	0.983 (0.974 to 0.992)	<0.001
LA volume index, 1 mL/m²	1.004 (1.002 to 1.006)	<0.001	1.004 (1.002 to 1.007)	0.001
Tricuspid regurgitation	1.012 (0.710 to 1.442)	0.95
MR regurgitant volume, 1 mL	1.012 (0.998 to 1.026)	0.10

LV ejection fraction were not adjusted for multivariable regressions because of collinearity (between LV end-systolic dimension and LV ejection fraction, R=−0.80).
A-FMR, atrial functional mitral regurgitation; LA, left atrium; LV, left ventricle; MR, mitral regurgitation; NYHA, New York Heart Association; V-FMR, ventricular functional mitral regurgitation.