Univariable and multivariable Cox regression for AVR-free survival in asymptomatic cohort
| Univariate HR (95% CI) | P value | Multivariate HR (95% CI) | P value | |
| Age (years) | 0.99 (0.97 to 1.02) | 0.54 | 0.98 (0.96 to 1.01) | 0.25 |
| Sex (male) | 1.20 (0.74 to 1.95) | 0.45 | 1.41 (0.85 to 2.34) | 0.13 |
| Hypertension | 1.29 (0.77 to 2.14) | 0.33 | ||
| Diabetes | 0.71 (0.33 to 1.56) | 0.40 | ||
| Previous PCI or myocardial infarction | 3.10 (0.96 to 10.04) | 0.06 | 3.12 (0.93 to 10.43) | 0.07 |
| Aortic valve area (per 0.01 cm2) | 0.98 (0.97 to 1.00) | 0.03 | ||
| Aortic mean gradient (mm Hg) | 1.02 (1.01 to 1.04) | 0.004 | 1.02 (1.01 to 1.04) | 0.006 |
| LV ejection fraction (%) | 1.00 (0.97 to 1.03) | 0.95 | ||
| EF1 (%) | 0.95 (0.92 to 0.99) | 0.01 | 0.96 (0.92 to 1.00) | 0.04 |
| Global longitudinal strain (%) | 1.06 (0.98 to 1.13) | 0.13 | ||
| LV mass (g) | 1.00 (1.00 to 1.01) | 0.08 | ||
| Late gadolinium enhancement fibrosis | 1.05 (0.58 to 1.90) | 0.86 | ||
| Valvulo-arterial impedance (mm Hg/mL/m2) | 1.24 (0.86 to 1.78) | 0.25 | ||
| Systemic arterial compliance (mm Hg/mL/m2) | 1.03 (0.50 to 2.11) | 0.94 | ||
| End-systolic wall stress (kdynes/cm2) | 1.01 (1.00 to 1.02) | 0.06 |
AVR, aortic valve replacement; EF1, first-phase ejection fraction; LV, left ventricle; PCI, percutaneous cardiac intervention.