Cox-regression for all cause mortality
| Variable | HR | CI | P value |
| TR grade | <0.001 | ||
| 1 | 1.573 | 0.930 to 2.661 | 0.091 |
| 2 | 1.892 | 1.066 to 3.359 | 0.029 |
| 3 | 2.934 | 1.569 to 5.488 | 0.001 |
| CKD (CKD-EPI GFR <60 mL/min) | 1.602 | 1.283 to 2.001 | <0.001 |
| LV systolic function | 0.014 | ||
| Mildly impaired (EF 45 –<55 %) | 1.076 | 0.811 to 1.426 | 0.613 |
| Moderately impaired (EF 35 –<45 %) | 1.421 | 1.040 to 1.942 | 0.027 |
| Severely impaired (EF <35 %) | 1.563 | 1.128 to 2.166 | 0.007 |
| NT-proBNP (age adjusted cut-offs according to ESC21) | 1.479 | 1.151 to 1.900 | 0.002 |
| TR progression (≥1 grade) | 1.442 | 1.112 to 1.814 | 0.006 |
| sPAP (≥40 mm Hg) | 1.435 | 1.249 to 1.649 | <0.001 |
| RV function (TAPSE <18.5 mm) | 1.431 | 1.143 to 1.792 | 0.002 |
| Aortic stenosis (at least moderate) | 1.391 | 1.092 to 1.773 | 0.008 |
| Mitral regurgitation (at least moderate) | 1.283 | 0.981 to 1.678 | 0.068 |
| Type 2 diabetes | 1.258 | 1.015 to 1.558 | 0.036 |
| Afib | 1.262 | 1.003 to 1.588 | 0.047 |
Cox-regression analysis with backward elimination (using a p value>0.100 as removal criterion) for all-cause mortality, including cardiac and non-cardiac risk factors. Risk factors included were: TR grade, CKD, LV systolic function, NT-proBNP, sPAP, RV function, aortic stenosis, mitral regurgitation, type 2 diabetes, Afib, coronary artery disease, hypertension, implantable cardiac device (pacemaker or defibrillator) and sex.
Bold values denote statistical significance at the p≤0.05 level.
Afib, atrial fibrillation; CKD, chronic kidney disease; ESC, European Society of Cardiology; GFR, glomerular filtration rate; LV, left ventricular; NT-proBNP, N-terminal pro brain natriuretic peptide; RV, right ventricular; sPAP, systolic pulmonary artery pressure; TAPSE, tricuspid annular plane systolic excursion; TR, tricuspid regurgitation.