Echocardiographic parameters at baseline echocardiography
| Total N=1650 | TR0 N=232 | TR1 N=1053 | TR2 N=287 | TR3 N=78 | P value | |
| Mean±SD | Mean±SD | Mean±SD | Mean±SD | Mean±SD | ||
| TR PISA (cm) | 0.5±0.2 | 0.0±0.0 | 0.4±0.2 | 0.7±0.2 | 0.9±0.3 | <0.001 |
| TR EROA (mm2) | 0.31±0.32 | 0.0±0.0 | 0.18±0.13 | 0.38±0.22 | 0.82±0.68 | <0.001 |
| TR vena contracta (mm) | 4.7±2.4 | 0.0±0.0 | 3.8±1.7 | 5.5±1.9 | 8.0±2.9 | <0.001 |
| TV annulus (mm) | 30.9±6.5 | 28.6±5.3 | 30.0±6.1 | 33.8±6.4 | 37.3±7.2 | <0.001 |
| sPAP (mm Hg) | 36.0±13.9 | 26.6±12.0 | 34.3±12.4 | 43.7±14.0 | 36.8±18.2 | <0.001 |
| TR Vmax (m/s) | 2.9±1.6 | 2.5±0.6 | 2.9±0.5 | 3.3±0.5 | 2.9±0.7 | 0.051 |
| TAPSE (mm) | 20.0±5.2 | 22.5±5.2 | 20.4±5.1 | 17.8±4.5 | 17.2±5.0 | <0.001 |
| TASV (mm) | 11.3±3.2 | 13.2±3.1 | 11.4±3.2 | 10.2±2.8 | 10.3±2.6 | <0.001 |
| LV-EF (%) | 46.8±14.3 | 52.5±11.0 | 47.1±14.2 | 43.0±15.4 | 42.6±14.8 | <0.001 |
| LVEDD (mm) | 51.2±9.1 | 49.2±8.2 | 51.1±9.0 | 53.1±9.5 | 51.8±9.7 | <0.001 |
| LVESD (mm) | 40.0±10.6 | 38.1±9.5 | 39.9±10.5 | 41.8±11.1 | 40.1±11.5 | 0.002 |
| RV1 (mm) | 37.1±7.5 | 33.1±6.0 | 36.3±6.9 | 41.0±7.1 | 44.5±8.1 | <0.001 |
| RV2 (mm) | 26.6±7.0 | 24.8±6.5 | 25.9±6.7 | 28.7±7.1 | 32.4±7.6 | <0.001 |
| RV3 (mm) | 66.0±10.2 | 67.3±10.4 | 65.4±10.0 | 66.5±10.5 | 68.8±10.4 | 0.009 |
| RV FAC (%) | 37.4±18.8 | 39.9±17.4 | 38.3±20.4 | 33.1±13.3 | 34.5±12.0 | <0.001 |
| RV area end diastolic (cm2) | 22.3±10.4 | 22.1±10.9 | 21.5±10.2 | 24.0±10.0 | 28.8±10.6 | <0.001 |
| MPI Index (%) | 0.5±0.2 | 0.5±0.2 | 0.5±0.2 | 0.5±0.2 | 0.6±0.3 | 0.204 |
Bold values denote statistical significance at the p≤0.05 level
EROA, effective regurgitant orifice area; FAC, fractional area change; LVEDD, left ventricular end-diastolic diameter; LV-EF, left ventricular ejection fraction; LVESD, left ventricular end-systolic diameter; MPI, myocardial performance index; ;PISA, proximal isovelocity surface area; RV, right ventricular, 1 basal, 2 mid, 3 longitudinal; sPAP, systolic pulmonary artery pressure; TAPSE, tricuspid annular plane systolic excursion; TASV, tricuspid annular systolic velocity; TR, tricuspid regurgitation; TV, tricuspid valve.