Total N=1650 | TR 0 N=232 | TR 1 N=1053 | TR 2 N=287 | TR 3 N=78 | P value | |
Mean±SD or % | Mean±SD or % | Mean±SD or % | Mean±SD or % | Mean±SD or % | ||
Age in years | 73.2±10.9 | 70.6±12.8 | 73.0±10.8 | 75.7±9.3 | 74.5±9.9 | <0.001 |
Female gender | 42.8 | 37.5 | 40.9 | 50.7 | 55.1 | 0.001 |
BMI (kg/m2) | 27.9±5.1 | 29.8±5.5 | 27.9±4.9 | 26.7±5.1 | 26.9±5.0 | <0.001 |
CV risk factors | ||||||
Hypertension | 92.7 | 91.7 | 93.0 | 92.3 | 93.5 | 0.892 |
Dyslipidaemia | 69.8 | 73.2 | 71.3 | 64.7 | 58.4 | 0.013 |
Comorbidities general | ||||||
Diabetes mellitus | 33.5 | 38.3 | 31.4 | 35.3 | 39.0 | 0.107 |
CKD (eGFR <60 mL/min) | 45.6 | 32.6 | 44.2 | 56.8 | 61.5 | <0.001 |
COPD | 15.5 | 12.3 | 14.8 | 18.5 | 23.4 | 0.051 |
Comorbidities cardiac | ||||||
Pulmonary hypertension | ||||||
Unlikely* | 51.5 | 88.8 | 53.0 | 18.1 | 42.3 | <0.001 |
Possible* | 26.1 | 6.5 | 28.2 | 33.4 | 28.2 | |
Likely* | 22.5 | 4.7 | 18.8 | 48.4 | 29.5 | |
Atrial fibrillation | 48.3 | 25.9 | 44.7 | 70.3 | 80.5 | <0.001 |
DCM | 10.7 | 6.6 | 10.8 | 13.0 | 13.0 | 0.109 |
Coronary artery disease | 57.9 | 57.8 | 59.8 | 53.8 | 48.1 | 0.089 |
Aortic stenosis (at least moderate) | 19.5 | 20.3 | 21.5 | 13.9 | 11.5 | <0.001 |
Prior aortic valve replacement | 9.1 | 10.3 | 8.2 | 11.8 | 7.7 | 0.226 |
Mitral regurgitation (at least moderate) | 18.8 | 3.0 | 13.8 | 53.2 | 54.9 | <0.001 |
Prior mitral valve replacement/repair | 4.6 | 2.6 | 3.8 | 8.0 | 9.0 | 0.003 |
Prior cardiac device | 22.6 | 10.5 | 21.5 | 32.9 | 35.1 | <0.001 |
Laboratory results | ||||||
NT-proBNP (n=995) | 3610±4766 | 1264±1783 | 3461±4695 | 5264±5025 | 6209±6689 | <0.001 |
CKD-EPI GFR (ml/min) (n=1244) | 64.4±27.1 | 71.0±29.3 | 65.6±26.4 | 56.4±27.0 | 55.5±21.3 | <0.001 |
Bold values denote statistical significance at the p≤0.05 level.
*The probability of pulmonary hypertension was estimated by the peak tricuspid regurgitation velocity and graded according to European Society of Cardiology guidelines.17 18
BMI, body mass index; CV, cardiovascular; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; COPD, chronic obstructive pulmonary disease; DCM, dilative cardiomyopathy; NT-proBNP, N-terminal pro brain natriuretic peptide.;