Patient characteristics
| Total population (n=423) | DETERMINE score <8 (n=207) | DETERMINE score ≥8 (n=216) | P value | |
| Age, years | 56 (50–66) | 56 (49–65) | 57 (51–66) | 0.159 |
| Female, n (%) | 71 (17) | 42 (20) | 29 (13) | 0.059 |
| Body mass index, kg/m² | 26 (25–29) | 26 (25–29) | 26 (24–29) | 0.401 |
| Hypertension, n (%) | 212 (50) | 98 (47) | 114 (53) | 0.264 |
| Hyperlipidaemia, n (%) | 239 (57) | 121 (59) | 118 (55) | 0.428 |
| Diabetes mellitus, n (%) | 41 (10) | 20 (11) | 22 (10) | 0.727 |
| Current smoker, n (%) | 233 (55) | 122 (59) | 111 (51) | 0.119 |
| Family history, n (%) | 144 (34) | 76 (37) | 68 (32) | 0.298 |
| Anterior infarct localisation, n (%) | 198 (47) | 60 (29) | 138 (64) | <0.001 |
| TIMI flow 0 pre-pPCI, n (%) | 264 (62) | 121 (59) | 143 (66) | 0.100 |
| TIMI flow 3 post-pPCI, n (%) | 376 (89) | 190 (92) | 186 (86) | 0.063 |
| Total ischaemia time, min | 186 (120–307) | 179 (108–285) | 195 (126–340) | 0.124 |
| Peak hs-cTnT, ng/L | 4890 (2190–8574) | 3117 (1320–5183) | 6957 (4388–10 900) | <0.001 |
| Peak hs-CRP, mg/L | 23 (12–46) | 20 (9–33) | 28 (15–57) | <0.001 |
| Peak NT-proBNP, ng/L | 1165 (560–2152) | 779 (424–1523) | 1553 (758–3044) | <0.001 |
| DETERMINE score | 8 (5–11) | 5 (2–6) | 11 (9–13) | <0.001 |
| Selvester score | 5 (3–8) | 3 (2–5) | 7 (5–9) | <0.001 |
| CMR parameters | ||||
| LVEDV, mL | 148 (125–170) | 144 (121–163) | 154 (128–178) | 0.003 |
| LVESV, mL | 69 (54–86) | 61 (49–80) | 75 (58–96) | <0.001 |
| LVEF, % | 53 (45–59) | 55 (49–61) | 50 (42–56) | <0.001 |
| LV global longitudinal strain, % | −12.0 (−14.1 to −9.7) | −13.4 (−15.4 to −11.3) | −10.8 (−12.8 to −8.8) | <0.001 |
| LV global radial strain, % | 26.3 (20.3–31.9) | 27.3 (21.9–33.2) | 25.6 (19.4–30.8) | 0.005 |
| LV global circumferential strain, % | −14.2 (−16.0 to −11.8) | −15.0 (−16.7 to −12.9) | −13.0 (−14.9 to −10.9) | <0.001 |
| IS, % of LVMM | 16 (8−24) | 11 (4−17) | 21 (14−28) | <0.001 |
| MVO presence | 230 (54) | 79 (38) | 151 (70) | <0.001 |
| MVO extent, % of LVMM | 0.4 (0.0–1.9) | 0.0 (0.0–0.9) | 1.2 (0.0–3.6) | <0.001 |
CMR, cardiac magnetic resonance imaging; hs-CRP, high-sensitivity C reactive protein; hs-cTnT, high-sensitivity cardiac troponin T; IS, infarct size; LVEDV, left ventricular end-diastolic volume; LVEF, left ventricular ejection fraction; LVESV, left ventricular end-systolic volume; LVMM, left ventricular myocardial mass; MVO, microvascular obstruction; NT-proBNP, N-terminal pro-B-type natriuretic peptide; pPCI, primary percutaneous coronary intervention.