Differences in CHA2DS2-VASc components at baseline and during follow-up, and the delta values of patients with solitary AFL and AFL developing into AF
| CHA2DS2-VASc components | At baseline | During follow-up | Delta (follow-up—baseline) | ||||||
| Solitary AFL (n=4101) | AFL then AF (n=4101) | STD | Solitary AFL (n=4101) | AFL then AF (n=4101) | STD | Solitary AFL (n=4101) | AFL then AF (n=4101) | STD | |
| Female | 1570 (38.3) | 1570 (38.3) | <0.01 | － | － | － | － | － | － |
| Age group | － | － | － | ||||||
| 20–64 (score 0) | 1212 (29.6) | 1212 (29.6) | <0.01 | 1161 (28.3) | 1134 (27.7) | 0.02 | － | － | － |
| 65–74 (score 1) | 1201 (29.3) | 1201 (29.3) | <0.01 | 1159 (28.3) | 1168 (28.5) | −0.02 | － | － | － |
| ≥75 (score 2) | 1688 (41.2) | 1688 (41.2) | <0.01 | 1781 (43.4) | 1799 (43.9) | −0.02 | － | － | － |
| Delta of age | － | － | － | 0.04±0.18 | 0.05±0.21 | −0.06 | |||
| Heart failure | 492 (12.0) | 521 (12.7) | −0.02 | 874 (21.3) | 1428 (34.8) | −0.30 | 382 (9.3) | 907 (22.1) | −0.36 |
| Hypertension | 2383 (58.1) | 2382 (58.1) | <0.01 | 2762 (67.3) | 2824 (68.9) | −0.03 | 379 (9.2) | 442 (10.8) | −0.05 |
| Diabetes mellitus | 771 (18.8) | 677 (16.5) | 0.06 | 876 (21.4) | 775 (18.9) | 0.06 | 105 (2.6) | 98 (2.4) | 0.01 |
| Stroke/SE | 530 (12.9) | 547 (13.3) | −0.01 | 732 (17.8) | 1068 (26.0) | −0.20 | 202 (4.9) | 521 (12.7) | −0.28 |
| Vascular disease | 1658 (40.4) | 1690 (41.2) | −0.02 | 2137 (52.1) | 2406 (58.7) | −0.13 | 479 (11.7) | 716 (17.5) | −0.16 |
| CHA2DS2-VASc score | 3.1±1.7 | 3.1±1.7 | <0.01 | 3.5±1.8 | 3.9±1.8 | −0.20 | 0.46±0.78 | 0.83±1.01 | −0.40 |
| Proposed A2C2S2-VASc score | 2.4±1.6 | 2.4±1.6 | −0.02 | 2.8±1.8 | 3.3±1.9 | −0.28 | 0.44±0.84 | 0.92±1.17 | −0.47 |
AF, atrial fibrillation; AFL, atrial flutter; SE, thromboembolism; STD, standardised mean difference.