Summary of findings and GRADE assessment results
| Outcome | No of studies | Risk of bias | Inconsistency | Indirectness | Imprecision | Publication bias | Total number of patients | Effect size* (95% CI) | Quality of evidence |
| 30-Day mortality | 5 | Low | Low | Low | High† | Low | 1528 | 1.00 (0.55 to 1.81) | Very low |
| One-year mortality | 4 | Low | Low | Low | Low | Low | 211 | 1.93 (1.16 to 3.22) | Low |
| Stroke | 6 | Low | Low | Low | High† | Low | 1588 | 1.08 (0.40 to 2.87) | Very low |
| Paravalvular leakage | 5 | Low | Low | Low | Low | Low | 1537 | 14.89 (6.89 to 32.16) | Moderate‡ |
| Kidney injury | 4 | Low | Low | Low | Low | Low | 1428 | 0.38 (0.21 to 0.69) | Moderate‡ |
| AF | 5 | Low | High§ | Low | High† | Low | 1514 | 0.37 (0.10 to 1.32) | Very low |
| Major bleeding | 4 | Low | Low | Low | High† | Low | 716 | 1.24 (0.46 to 3.35) | Very low |
| Hospitalisation duration | 6 | Low | High§ | Low | Low | Low | 1588 | 1.92 (0.61 to 3.24) | Very low |
*All effect sizes, with the exception of hospitalisation durations (presented as mean differences), are presented as relative risk ratios.
†Crosses threshold of no difference.
‡Upgraded due to large effect size.
§High I2 and non-overlapping confidence intervals.
AF, atrial fibrillation; GRADE, Grading of Recommendations Assessment, Development and Evaluation.