Baseline characteristics
| | Symptomatic* patients with treatment decision (n=1608) | Asymptomatic* patients with treatment decision (n=392) | ||||
| Assigned to AVR n=1225 n (%) or mean±SD | Denied AVR n=383 n (%) or mean±SD | P value | No AVR n=238 n (%) or mean±SD | Assigned to AVR n=154 n (%) or mean±SD | P value | |
| Age (years) | 77.7±9.4 | 79.8±9.9 | <0.001 | 75.4±11.3 | 74.8±10.7 | 0.633 |
| Female gender | 600/1225 (49.0) | 198/383 (51.7) | 0.353 | 93/238 (39.1) | 63/154 (40.9) | 0.717 |
| BMI (kg/m2) | 27.6±5.2 | 27.1±5.8 | 0.116 | 27.3±5.0 | 26.7±5.2 | 0.206 |
| Severe frailty | 41/1221 (3.4) | 28/371 (7.5) | 0.001 | 10/229 (4.4) | 4/154 (2.6) | 0.366 |
| EuroSCORE II (%) | 4.1±4.5 | 4.8±6.2 | 0.047 | 1.9±1.7 | 2.2±2.6 | 0.243 |
| Comorbidity | ||||||
| Renal insufficiency† | 287/1109 (25.9) | 126/341 (37.0) | <0.001 | 39/204 (19.1) | 21/145 (14.5) | 0.258 |
| COPD | 138/1225 (11.3) | 60/383 (15.7) | 0.022 | 9/236 (3.8) | 8/154 (5.2) | 0.514 |
| Diabetes‡ | 108/1225 (8.8) | 35/383 (9.1) | 0.847 | 18/236 (7.6) | 5/154 (3.2) | 0.073 |
| AF | 173/1140 (15.2) | 59/337 (17.5) | 0.301 | 21/208 (10.1) | 19/144 (13.2) | 0.368 |
| Endocarditis | 4/1225 (0.3) | 4/383 (1.0) | 0.098 | 2/236 (0.8) | 0/154 (0.0) | 0.521 |
| Previous cardiac surgery | 88/1225 (7.2) | 34/383 (8.9) | 0.275 | 14/237 (5.9) | 4/154 (2.6) | 0.127 |
| 2-year life expectancy <25%§ | 80/817 (9.8) | 41/275 (14.9) | 0.019 | 4/150 (2.7) | 5/104 (4.8) | 0.493 |
*Symptomatic defined as having ≥1 of the following (presumed to be AS-related): chest pain, shortness of breath, dizziness on exertion/syncope.
†Creatinine clearance rate <50 mL/min or dialysis.
‡Insulin dependent.
§2-yearlife expectancy <25% was assessed by the dedicated nurses and physicians.
AF, atrial fibrillation; AVR, aortic valve replacement; BMI, body mass index; COPD, chronic obstructive pulmonary disease.