Echocardiographic parameters
| | Symptomatic* patients with treatment decision (n=1608) | Asymptomatic* patients with treatment decision (n=392) | ||||
| Assigned to AVR n=1225 n (%) or mean±SD | Denied AVR n=383 n (%) or mean±SD | P value | No AVR n=238 n (%) or mean±SD | Assigned to AVR n=154 n (%) or mean±SD | P value | |
| Indexed AVA (cm2/m2) | 0.38±0.10 | 0.41±0.12 | <0.001 | 0.44±0.11 | 0.40±0.10 | 0.001 |
| Vmax (m/s) | 4.33±0.67 | 4.23±0.68 | 0.014 | 4.29±0.56 | 4.42±0.62 | 0.034 |
| Mean AV gradient (mm Hg) | 48.0±14.6 | 44.6±15.4 | <0.001 | 47.0±12.7 | 48.8±14.4 | 0.211 |
| LVEF (%) | 54.9±12.0 | 57.1±12.5 | 0.002 | 61.4±9.5 | 57.1±10.8 | <0.001 |
| PASP (mm Hg) | 39.9±12.9 | 39.4±14.1 | 0.613 | 35.0±10.8 | 37.6±10.7 | 0.047 |
| AVA <1 cm2 and mean AV gradient <40 mmHg | 280/1199 (23.4) | 119/373 (31.9) | 0.001 | 48/236 (20.3) | 26/152 (17.1) | 0.429 |
| Aortic regurgitation grade III/IV | 82/1166 (7.0) | 28/367 (7.6) | 0.699 | 27/224 (12.1) | 10/149 (6.7) | 0.091 |
| Mitral regurgitation grade III/IV | 109/1199 (9.1) | 65/371 (17.5) | <0.001 | 19/224 (8.5) | 6/153 (3.9) | 0.081 |
| Mitral stenosis grade III/IV | 19/1137 (1.7) | 5/348 (1.4) | 0.762 | 5/208 (2.4) | 3/146 (2.1) | 1.000 |
| Tricuspid regurgitation grade III/IV | 76/1157 (6.6) | 45/358 (12.6) | <0.001 | 13/221 (5.9) | 6/149 (4.0) | 0.428 |
| LVH† | 759/1214 (62.5) | 227/367 (61.9) | 0.817 | 136/231 (58.9) | 88/152 (57.9) | 0.849 |
| Relative wall thickness | 0.52±0.15 | 0.55±0.16 | 0.011 | 0.53±0.15 | 0.52±0.14 | 0.383 |
| LV mass (g) | 243.2±75.9 | 232.8±82.5 | 0.047 | 237.7±72.6 | 252.2±76.6 | 0.091 |
| Indexed LV mass (g/m2) | 131.3±39.9 | 133.0±44.3 | 0.546 | 129.8±39.0 | 137.0±39.1 | 0.121 |
| LV-ESD (mm) | 33.0±11.3 | 29.9±9.2 | <0.001 | 28.2±6.2 | 31.2±8.3 | 0.001 |
| LV-EDD (mm) | 48.8±9.9 | 46.0±7.9 | <0.001 | 46.5±7.0 | 48.4±7.9 | 0.022 |
| IVS (mm) | 13.6±2.5 | 13.8±2.8 | 0.320 | 13.9±2.8 | 13.9±2.5 | 0.984 |
| PW (mm) | 12.1±2.3 | 12.1±2.7 | 0.979 | 12.0±2.2 | 12.1±2.2 | 0.759 |
| LVEF <30% | 40/1168 (3.4) | 9/365 (2.5) | 0.363 | 2/229 (0.9) | 4/144 (2.8) | 0.211 |
| LVEF ≥50% and PASP <55 mm Hg | 743/1094 (67.9) | 238/340 (70.0) | 0.470 | 189/211 (89.6) | 108/138 (78.3) | 0.004 |
*Symptomatic defined as having ≥1 of the following (presumed to be AS related): chest pain, shortness of breath, dizziness on exertion/syncope.
†>12 mm in thickness.
AV, aortic valve; AVA, aortic valve area; IVS, interventricular septum; LV, left ventricular; LV-EDD, left ventricular end diastolic diameter; LVEF, left ventricular ejection fraction; LV-ESD, left ventricular end systolic diameter; PASP, pulmonary artery systolic pressure; PW, posterior wall; Vmax, peak AV jet velocity.