Table 2

Echocardiographic parameters


Symptomatic* patients with treatment decision
(n=1608)
Asymptomatic* patients with treatment decision
(n=392)
Assigned to AVR
n=1225
n (%) or mean±SD
Denied AVR
n=383
n (%) or mean±SD
P valueNo AVR
n=238
n (%) or mean±SD
Assigned to AVR
n=154
n (%) or mean±SD
P value
Indexed AVA (cm2/m2)0.38±0.100.41±0.12<0.0010.44±0.110.40±0.100.001
Vmax (m/s)4.33±0.674.23±0.680.0144.29±0.564.42±0.620.034
Mean AV gradient (mm Hg)48.0±14.644.6±15.4<0.00147.0±12.748.8±14.40.211
LVEF (%)54.9±12.057.1±12.50.00261.4±9.557.1±10.8<0.001
PASP (mm Hg)39.9±12.939.4±14.10.61335.0±10.837.6±10.70.047
AVA <1 cm2 and mean AV gradient <40 mmHg280/1199 (23.4)119/373 (31.9)0.00148/236 (20.3)26/152 (17.1)0.429
Aortic regurgitation grade III/IV82/1166 (7.0)28/367 (7.6)0.69927/224 (12.1)10/149 (6.7)0.091
Mitral regurgitation grade III/IV109/1199 (9.1)65/371 (17.5)<0.00119/224 (8.5)6/153 (3.9)0.081
Mitral stenosis grade III/IV19/1137 (1.7)5/348 (1.4)0.7625/208 (2.4)3/146 (2.1)1.000
Tricuspid regurgitation grade III/IV76/1157 (6.6)45/358 (12.6)<0.00113/221 (5.9)6/149 (4.0)0.428
LVH†759/1214 (62.5)227/367 (61.9)0.817136/231 (58.9)88/152 (57.9)0.849
Relative wall thickness0.52±0.150.55±0.160.0110.53±0.150.52±0.140.383
LV mass (g)243.2±75.9232.8±82.50.047237.7±72.6252.2±76.60.091
Indexed LV mass (g/m2)131.3±39.9133.0±44.30.546129.8±39.0137.0±39.10.121
LV-ESD (mm)33.0±11.329.9±9.2<0.00128.2±6.231.2±8.30.001
LV-EDD (mm)48.8±9.946.0±7.9<0.00146.5±7.048.4±7.90.022
IVS (mm)13.6±2.513.8±2.80.32013.9±2.813.9±2.50.984
PW (mm)12.1±2.312.1±2.70.97912.0±2.212.1±2.20.759
LVEF <30%40/1168 (3.4)9/365 (2.5)0.3632/229 (0.9)4/144 (2.8)0.211
LVEF ≥50% and PASP <55 mm Hg743/1094 (67.9)238/340 (70.0)0.470189/211 (89.6)108/138 (78.3)0.004
  • *Symptomatic defined as having ≥1 of the following (presumed to be AS related): chest pain, shortness of breath, dizziness on exertion/syncope.

  • †>12 mm in thickness.

  • AV, aortic valve; AVA, aortic valve area; IVS, interventricular septum; LV, left ventricular; LV-EDD, left ventricular end diastolic diameter; LVEF, left ventricular ejection fraction; LV-ESD, left ventricular end systolic diameter; PASP, pulmonary artery systolic pressure; PW, posterior wall; Vmax, peak AV jet velocity.