Table 1

Clinical characteristics and echocardiographic parameters in female patients corrected for TOF grouped by parity

TOF without children
TOF with children
P valueOR
(95% CI)
P value
Age, years37±1030±940±9<0.01
Height, cm165±7165±7165±70.96
Weight, kg68±1367±1169±130.53
HR, bpm69±1373±1067±130.07
Transannular patch (%)30 (37)11 (44)19 (36)0.53
SBP, mm Hg116±11115±9117±120.59
DBP, mm Hg71±1072±870±110.50
QTc duration, ms460±31460±29460±320.96
Exercise capacity, W131±27127±24132±280.53
NYHA class1 (1–3)1 (1–3)1 (1–3)0.11
NT-ProBNP, ng/L174 (30–836)110 (30–372)198 (49–836)0.11
QRS duration, ms132 (82–174)124 (86–162)134 (82–174)0.62
RV EDV, mL21.7±4.620.5±4.821.9±4.00.18
RV ESV, mL11.3±2.910.8±2.911.3±2.70.52
RV FAC, %47.8±7.247.1±7.448.1±7.30.58
RV D3, cm7.3±0.77.1±0.77.4± (1.1 to 4.3)0.04
PV vel, m/s1.9±0.61.9±0.71.9±0.50.91
Mod-sev PV reg14 (17%)5 (22%)9 (16%)0.48
LV MD, ms43.3±1441.4±1045.3±100.4
LV GLS, %−18.9±3.3−19.2±3.1−17.5±3.60.1
RV MD, ms42±1338±1243±140.1
RV GLS, %−19.1±4.1−19.7±4.1−18.3±4.10.28
RVOT, cm
LVEF, %55±856±854±80.39
  • Data are presented as mean±SD or median with range, as appropriate; p value from Student’s t-test, Mann-Whitney U or χ2 test as appropriate, and multivariable logistic regression adjusted for age.

  • DBP, diastolic blood pressure; EDV, end-diastolic volume; ESS, end-systolic strain; ESV, end-systolic volume; GLS, global longitudinal strain; HR, heart rate; LV, left ventricular; LVEF, left ventricular ejection fraction; MD, mechanical dispersion; NT-proBNP, N-terminal pro-brain natriuretic peptide; NYHA, New York Heart Association classification; PV, pulmonary valve; RV, right ventricular; RV D3, right ventricular longitudinal diameter; RV FAC, right ventricular fractional area change; RVOT, right ventricular outflow tract; SBP, systolic blood pressure; TOF, tetralogy of Fallot; VA, ventricular arrhythmia.