Table 2

Clinical characteristics and echocardiographic parameters in female patients corrected for TOF grouped by number of pregnancies

pregnancy n=25 (31%)
pregnancy n=19 (24%)
pregnancy n=36 (45%)
P valueOR
(95% CI)
P value
Age, years29±1038±1140±7<0.01
Height, cm165±7166±4165±70.55
Weight, kg67±1163±669±150.55
HR, bpm73±1063±1367±130.23
SBP, mm Hg115±9111±14117±100.84
DBP, mm Hg71±765±1071±110.39
QTc duration, ms460±30458±30462±330.83
Exercise capacity, W127±24131±25133±290.82
NYHA class1 (1–3)1 (1–2)1 (1–3)0.53
NT-ProBNP, ng/L109 (30–372)177 (110–836)126 (49–558)0.50
QRS duration, ms124 (86–162)148 (94–174)134 (82–172)0.69
TOF with VA (n=17)1 (4%)6 (31%)10 (28%)0.042.4 (1.1 to 5.4)0.03
RV EDV, mL20.5±4.822.8±4.821.7±4.10.25
RV ESV, mL10.8±2.912.1±3.711±2.10.33
RV FAC, %47±746±849±60.46
RV D3, cm7.0±0.77.6±0.97.3±0.60.05
PV vel, m/s1.9±0.72.0±0.51.8±0.50.65
Mod-sev PV reg5 (22%)3 (15%)9 (25%)0.76
LV MD, ms41±1045±1145±160.59
LV GLS, %−19.0±3.0−18.8±3.6−18.7±3.20.95
RV MD, ms38±1243±1643±130.41
RV GLS, %−19.2±5.0−18.1±3.8−19.4±3.20.54
RVOT, cm2.9±0.33.2±0.52.8±0.50.07
LVEF, %57±756±954±80.39
  • Data are presented as mean±SD or median with range, as appropriate; p value from Student’s t-test, Mann-Whitney U, χ2 test or ANOVA as appropriate, and multivariable logistic regression adjusted for age.

  • DBP, diastolic blood pressure; EDV, end-diastolic volume; ESS, end-systolic strain; ESV, end-systolic volume; GLS, global longitudinal strain; HR, heart rate; LV, left ventricular; LVEF, left ventricular ejection fraction; MD, mechanical dispersion; NT-proBNP, N-terminal pro-brain natriuretic peptide; NYHA, New York Heart Association classification; PV, pulmonary valve; RV, right ventricular; RV D3, right ventricular longitudinal diameter; RV FAC, right ventricular fractional area change; RVOT, right ventricular outflow tract; SBP, systolic blood pressure; TOF, tetralogy of Fallot; VA, ventricular arrhythmia.