Patients’ characteristics
| Clinical parameters | Bleeding | ||
| None | Non-major | Adj. major | |
| N (%) | 1345 (91.3) | 98 (6.7) | 30 (2.0) |
| Men (%) | 67 | 57 | 70 |
| Age (years) | 58 (0.3) | 61 (0.1) | 65 (1.3) |
| Ancestry (white,%) | 79 | 90 | 80 |
| BMI (kg/m2) | 28 (0.1) | 27 (0.5) | 27 (0.8) |
| H/O Cigarette smoking (%) | 69 | 68 | 69 |
| H/O Hypertension (%) | 42 | 43 | 36 |
| H/O Diabetes mellitus (%) | 15 | 11 | 19 |
| H/O Previous angina pectoris (%) | 85 | 92 | 87 |
| H/O Myocardial infarction (%) | 41 | 34 | 21 |
| FH/O CAD (%) | 39 | 35 | 23 |
| On diuretics at adm. (%) | 16 | 20 | 30 |
| Aspirin within 24 hours before adm. (%) | 48 | 43 | 45 |
| Aspirin dose before adm. (mg/d) | 325 (0–325) | 325 (0–325) | 325 (0–325) |
| R/ Hypercholesterolaemia (%) | 20 | 15 | 7 |
| SBP (mm Hg)* | 132 (0.6) | 132 (1.8) | 129 (2.8) |
| Platelet count (.109/L)* | 264 (2.0) | 275 (9.2) | 269 (14.2) |
| HB (mmol/L)* | 8.8 (0.0) | 8.6 (0.1) | 9.3 (0.7) |
| HT (%)* | 41.5 (0.1) | 40.9 (0.5) | 40.5 (1.4) |
| aPTT >1.5 URL at adm. (%) | 12 | 11 | 13 |
| WBC count (.109/L)* | 8.7 | 9.0 | 10.6 |
| Creatinine (μmol/L)* | 97 (80–115) | 88 (80–106) | 97 (71–117) |
| Invasive treatment arm (%) | 49 | 61 | 62 |
| rt-PA (%) | 48 | 57 | 73 |
| Fibrinogen 12 hours (g/L) | 2.7 (0.0) | 2.6 (0.1) | 2.4 (0.1) |
| FDP 12 h min (mg/L) | 0.22 (0.11) | 0.24 (0.24) | 1.20 (0.8) |
| Heparin dose d. 1–5 (U/d) | 17 620 (169) | 16 835 (565) | 15 263 (1 402) |
| Aspirin dose d. 1–5 (mg/d) | 240 (2.4) | 234 (10.7) | 181 (24.4) |
| HB d. 1–5 (mmol/L) | 12.9 (0.0) | 12.0 (0.2) | 11.6 (0.3) |
| Platelet count d. 1–5 (.109/L) | 238 (1.9) | 242 (7.6) | 202 (12.3) |
| CKmax (IU/L) | 149 (82–424) | 180 (83–436) | 390 (174–1104) |
| CKmax (times URL) | 0.7 (0.4–2.0) | 0.9 (0.4–2.0) | 1.6 (0.9–5.7) |
| CKmax <200 IU/L/<URL (%) | 60/59 | 55/53 | 30/40 |
| Time to peak CK (h) | 4 (0–24) | 4 (12–48) | 4 (24–72) |
| Time to bleeding (h)† | n.a. | 96 (72–120) | 72 (48–144) |
Patients by adjudicated (adj.), major bleeding (primary outcome) versus other or no bleeding. Data are counts, percentages, mean (SD) or median (IQR), rounded to whole numbers where applicable.
Oral anticoagulant drug use was an exclusion criterion.
*At hospital admission (baseline).
†Derived from days.
Adm., admission; aPTT, activated partial thromboplastin time; BMI, body mass index; CAD, coronary artery disease; CKmax, peak plasma creatine kinase during admission; d, day; FDP, fibrin(ogen) degradation products; (F)H/O, (family) history of; h, hour; HB, haemoglobin; HT, haematocrit; n.a, not applicable; R/, drug therapy for; rt-PA, recombinant tissue-type plasminogen activator; SBP, systolic blood pressure; URL, upper reference limit; WBC, white blood cell.