Table 1

Baseline demographic and clinical characteristics

All patients (n=1252)CAD (n=124)No CAD (n=1128)Difference (95% CI)
Age, years64.7±15.575.9±9.463.5±15.612.4 (9.6 to 15.2)
Female sex454 (36.3%)22 (17.7%)432 (38.3%)−20.6 (−29.4 to 11.7)
Smokers97 (7.7%)34 (27.4%)63 (5.6%)21.8 (17.0 to 26.7)
Obesity46 (3.7%)10 (8.1%)36 (3.2%)4.9 (1.4 to 8.4)
Hypertension498 (39.8%)98 (79.0%)400 (35.5%)43.6 (34.8 to 52.3)
Hyperlipidaemia93 (7.4%)39 (31.5%)54 (4.8%)26.7 (22.0 to 31.3)
Diabetes mellitus191 (15.3%)37 (29.8%)154 (13.7%)16.2 (9.6 to 22.8)
Chronic kidney disease104 (8.3%)26 (21.0%)78 (6.9%)14.1 (9.0 to 19.1)
Prior CVE103 (8.2%)13 (10.5%)90 (8.0%)2.5 (−2.6 to 7.6)
LVEF*54.8±9.649±959±710 (8.1 to 11.9)
LVEF <35%38 (3.0%)20 (16.1%)18 (1.6%)14.5 (11.5 to 17.6)
Atrial fibrillation108 (8.6%)18 (14.5%)90 (8.0%)6.5 (1.3 to 11.7)
COPD75 (6.0%)15 (12.1%)60 (5.3%)6.8 (2.4 to 11.2)
Asthma19 (1.5%)1 (0.8%)18 (1.6%)−0.8% (−3.1% to 1.5%)
Active cancer35 (2.8%)5 (4.0%)30 (2.7%)1.4 (−1.7 to 4.4)
Coronary artery disease124 (9.9%)124 (100%)
Prior MI61 (49%)61 (49%)
Prior PCI100 (81%)100 (81%)
Prior CABG20 (16%)20 (16%)
CAD medically treated10 (8%)10 (8%)
CAD presentation
Chronic coronary syndrome57 (4.6%)57 (46%)
Prior ACS67 (5.3%)67 (54%)
NSTE-ACS47 (70%)47 (70%)
STEMI20 (30%)20 (30%)
Days from symptoms onset5.8±3.85.8±3.95.8±3.80.1 (−0.6 to 0.8)
  • Data are expressed as n (%) or mean±SD.

  • Obesity was defined as a body mass index ≥30 kg/m2. Chronic kidney disease was defined as an estimated glomerular filtration rate <60 mL/min/1.73 m2.

  • *LVEF data were available in 204/1252 (16%) of no CAD group and in 100% of CAD group.

  • ACS, acute coronary syndrome; CABG, coronary artery bypass grafting; CAD, coronary artery disease; COPD, chronic obstructive pulmonary disease; CVE, cerebrovascular event; LVEF, left ventricular ejection fraction; MI, myocardial infarction; NSTE-ACS, non-ST-segment elevation ACS; PCI, percutaneous coronary intervention; STEMI, ST-segment elevation myocardial infarction.