Observed findings from catheterisation, CMR and MRE in patients with and without diffuse myocardial fibrosis
| Total (n=25) | Myocardial fibrosis | P value | ||
| DMF+ (n=12) | DMF− (n=13) | |||
| Ejection fraction (%, CMR) | 54±7 | 56±5 | 53±8 | 0.17 |
| Haematocrit (%) | 45±4 | 45±5 | 45±4 | 0.89 |
| Native T1 values | 990±84 | 1025±60 | 958±93 | 0.04 |
| Baseline Fontan pressure (mm Hg) | 12±2 | 13±3 | 11±1 | 0.02 |
| Baseline ventricular end-diastolic pressure (mm Hg) | 9±2 | 10±2 | 8±2 | 0.03 |
| Baseline pulmonary vascular resistance (iWu) | 1.2±0.5 | 1.3±0.6 | 1.2±0.4 | 0.55 |
| Baseline aortic saturation (%) | 93±3 | 92±3 | 94±2 | 0.13 |
| Baseline cardiac index (L/min/m2) | 3.4±0.8 | 3.3±0.7 | 3.4±0.9 | 0.7 |
| Change in ventricular EDP after stress (mm Hg) | 4.3±2.1 | 4.4±0.6 | 4.1±0.6 | 0.69 |
| Change in Fontan pressure after stress (mm Hg) | 3.4±1.9 | 3.7±2.2 | 3.0±1.3 | 0.33 |
| Change in cardiac output after stress (L/min/m2) | 0.0±0.9 | −0.1±0.2 | 0.1±0.3 | 0.65 |
| Stress Fontan pressure (mm Hg) | 15±3 | 17±3 | 14±1 | 0.008 |
| Stress ventricular end-diastolic pressure (mm Hg) | 13±3 | 14±3 | 12±2 | 0.04 |
| Stress pulmonary vascular resistance (iWu) | 1.4±0.6 | 1.5±0.7 | 1.2±0.5 | 0.28 |
| Stress cardiac index (L/min/m2) | 3.3±1.2 | 3.1±1.0 | 3.5±1.3 | 0.44 |
| Liver Stiffness (n=17) | 4.1±0.7 | 4.5±0.3 (n=10) | 3.4±0.7 (n=7) | 0.066 |
Results are presented as mean±SD or frequency (%). P values in bold are statistically significant.
CMR, cardiac MRI; EDP, end-diastolic pressure; iWu, indexed Wood units; MRE, magnetic resonance elastography.