NTproBNP and hs-cTNT at four time points; total prepregnancy healthy cohort and subgroups
| NTproBNP (ng/l) | ||||
| Total cohort | A (10-12 gw) n=196 | B (20-25 gw) n=163 | C (peripartum) n=120 | D (postpartum) n=150 |
| Median (range) | 56 (5–312) | 47 (7–279) | 44 (5–990) | 51 (6–305) |
| Mean, (SD) | 67 (45) | 58 (45) | 75 (112) | 62 (44) |
| 95th percentile | 155 | 140 | 207 | 149 |
| n above 300 ng/l | 1 | 0 | 4 | 1 |
| p < 0.05 vs sample | B | A, D | n.s. | B |
| Selected vs non-selected | p=0.103 | p=0.935 | p=0.164 | p=0.431 |
| Selected cohort (no events) | A n=111 | B n=98 | C n=74 | D n=89 |
| Median (range) | 57 (5–239) | 50 (7–214) | 42 (5–402) | 52 (6–205) |
| Mean (SD) | 69 (42) | 58 (40) | 55 (53) | 62 (40) |
| 95th percentile | 155 | 139 | 155 | 151 |
| n above 300 ng/l | 0 | 0 | 1 | 0 |
| p <0.05 vs sample | B,C | A, D | A | B |
| Non-selected cohort | A n=85 | B n=65 | C n=46 | D n=61 |
| Median (range) | 49 (5–312) | 44 (9–279) | 53 (5–990) | 48 (9–305) |
| Mean (SD) | 65 (48) | 57 (52) | 107 (164) | 63 (48) |
| 95th percentile | 165 | 153 | 435 | 139 |
| n above 300 ng/l | 1 | 0 | 3 | 1 |
| p <0.05 vs sample | n.s. | n.s. | n.s. | n.s. |
| Total cohort | A n=196 | B n=163 | C n=119 | D n=150 |
| Median (range) | <5 (<5–6.1) | <5 (<5–10.5) | 5.21 (<5– 30.6) | <5 (<5–11.7) |
| Mean (SD) | 5.02 (0.13) | 5.03 (0.43) | 6.67 (3.32) | 5.08 (0.65) |
| 95th percentile | <5 | <5 | 12 | <5 |
| n above 14 ng/l | 0 | 0 | 3 | 0 |
| p < 0.05 vs sample | C | C | A, B, D | C |
| Selected vs non-selected | p=0.731 | p=0.222 | p=0.171 | p=0.362 |
| Selected cohort (no events) | A n=111 | B n=98 | C n=74 | D n=89 |
| Median (range) | <5 (5–6.1) | <5 (<5–<5) | 5.2 (<5– 22.1) | <5 (<5–11.7) |
| Mean (SD) | 5.02 (0.13) | <5 (0.00) | 6.3 (2.48) | 5.13 (0.84) |
| 95th percentile | <5 | <5 | 10.6 | <5 |
| n above 14 ng/l | 0 | 0 | 1 | 0 |
| p <0.05 vs sample | C | C | A, B, D | C |
| Non-selected cohort | A n=85 | B n=65 | C n=45 | D n=61 |
| Median (range) | <5 (<5–5.9) | <5 (<5–10.5) | 5.65 (<5–30.6) | <5 (<5–<5) |
| Mean (SD) | 5.02 (0.13) | 5.08 (0.68) | 7.32 (4.33) | <5 (0) |
| 95th percentile | <5 | <5 | 13.95 | <5 |
| n above 14 ng/l | 0 | 0 | 2 | 0 |
| p <0.05 vs sample | C | C | A, B, D | C |
Hs-cTNT levels below 5.0 are reported from lab as <5.0 without further grading. ‘P<0.05 vs sample’ shows time points with significant differences between the measurements. The selected subgroup consisted of prepregnancy healthy women with spontaneous conception, BMI <35 at first antenatal visit, a normal pregnancy and delivery that is, no miscarriage, no treatment with levothyroxine, no hypertensive disorders of pregnancy, not more than 1+proteinuria on one occasion and a vaginal non-assisted delivery at term without complications and no postpartum haemorrhage >1000 mL. The non-selected group were prepregnancy healthy women with any of the above conditions.
BMI, body mass index; hs-cTNT, high sensitive cardiac troponin T; n.s., non-significant; NTproBNP, N-terminal pro-brain natriuretic peptide.