Table 2

Multiple variable regression and backward stepwise regression showing relationship between frailty and SF-12 physical composite score

SF-12 PCS at baselineMultiple variable regression
(Adj R2=0.32)
Backwards stepwise regression
(Adj R2=0.33)
β (95% CI)P valueβ (95% CI)P value
Age−0.12 (−0.66 to 0.42)0.64
Female sex−3.58 (−7.24 to 0.59)0.05−2.90 (−6.11 to −0.32)0.07
BMI−0.14 (−0.51 to 0.23)0.45
Medical history
 Hypertension−1.15 (−4.66 to 2.36)0.52
 Diabetes mellitus−0.90 (−4.79 to 2.99)0.65
 Previous MI0.49 (−4.15 to 5.13)0.84
 Previous PCI−3.82 (−8.22 to 0.57)0.09−3.15 (−6.34 to 0.03)0.05
Baseline CCS class
 No angina0.000.060.000.06
 Class I−0.68 (−7.34 to 7.48)−0.81 (−7.50 to 5.87)
 Class II−2.31 (−8.78 to 4.17)−3.76 (−9.69 to 2.18)
 Class III−6.14 (−12.34 to 0.06)−6.41 (−16.44 to −0.64)
 Class IV−8.06 (−17.42 to 1.31)−2.67 (−8.76 to 3.40)
Baseline NYHA class
 Class I0.000.040.000.004
 Class II−4.68 (−11.07 to 1.70)−4.76 (−10.83 to 1.32)
 Class III−8.73 (−15.93 to −1.53)−9.77 (−16.44 to −3.12)
 Class IV−2.27 (−12.53 to 7.99)−2.92 (−12.19 to 6.35)
Charlson comorbidity score−0.74 (−1.47 to 0.14)0.14−0.96 (−1.72 to −0.21)0.01
GRACE 1-year mortality−0.05 (−0.21 to 0.11)0.54
EuroScore II0.84 (−0.39 to 0.56)0.73
Clinical presentation
 Stable angina0.000.13
 Unstable angina−4.61 (−10.03 to 0.81)
 NSTEMI0.52 (−3.96 to 5.00)
 STEMI6.54 (−3.05 to 16.13)
Fried frailty phenotype
 Not frail0.000.050.000.005
 Pre-frail−0.05 (−5.04 to 4.94)−1.44 (−6.05 to 3.17)
 Frail−5.42 (−11.89 to 1.04)−7.29 (−12.83 to 1.75)
Edmonton frailty score
 Not frail0.000.82
 Vulnerable−0.36 (−4.48 to 3.76)
 Mild frailty−3.01 (−8.36 to 2.33)
 Moderate frailty0.37 (−6.34 to 7.07)
 Severe frailty−0.77 (−9.84 to 8.29)