Severe (123) | Non-severe (160) | P value | |
Age, years | 76.4 (70.4 to 83.7) | 73.1 (63.5 to 80.1) | <0.001 |
Sex, % male (n) | 49.6% (61) | 45.0% (72) | 0.44 |
BMI, kg/m2 | 27.8 (24.2 to 32.9) | 28.4 (24.9 to 33.8) | 0.66 |
AVA, cm2 | 0.77 (0.63 to 0.86) | 0.90 (0.77 to 0.96) | <0.001 |
AVAi, cm2/m2 | 0.40 (0.33 to 0.45) | 0.45 (0.40 to 0.51) | <0.001 |
Vmax, m/s | 3.58 (3.28 to 3.79) | 3.44 (3.24 to 3.63) | 0.004 |
Mean gradient, mm Hg | 29.7 (25.5 to 33.1) | 27.0 (23.8 to 31.0) | <0.001 |
Peak gradient, mm Hg | 51.8 (43.0 to 57.2) | 47.3 (42.0 to 52.8) | 0.003 |
DI | 0.22 (0.19 to 0.26) | 0.26 (0.23 to 0.30) | <0.001 |
Ejection fraction, % | 55 (38 to 60) | 55 (55 to 61) | <0.001 |
SV, mL | 61.1 (50.6 to 73.7) | 71.2 (60.2 to 80.0) | <0.001 |
Indexed SV, mL/m2 | 32.5 (26.1 to 38.2) | 37.5 (30.7 to 42.8) | <0.001 |
LVOT diameter, cm | 2.02 (2.00 to 2.27) | 2.00 (2.00 to 2.20) | 0.20 |
LVIDd, cm | 4.59 (3.98 to 5.03) | 4.32 (3.93 to 4.80) | <0.001 |
LVIDs, cm | 3.17 (2.60 to 3.84) | 2.90 (2.50 to 3.30) | <0.001 |
BSA, m2 | 1.93 (1.72 to 2.10) | 1.90 (1.73 to 2.06) | 0.72 |
Data presented as median (25th percentile, 75th percentile) except where otherwise noted. 7 severe and 4 non-severe patients did not have reliable BMIs recorded, giving n=116 and 156 for this metric, respectively. 3 severe and 2 non-severe patients did not have LVID metrics, giving n=120 and 158, respectively.
AVA, aortic valve area; AVAi, indexed AVA; BMI, body mass index; BSA, body surface area; DI, dimensionless index; LVID, left ventricular internal dimension; LVIDd, LVID in diastole; LVIDs, LVID in systole; LVOT, left ventricle outflow tract; SV, stroke volume; Vmax, peak jet velocity.