Table 1

Cohort characteristics

All (807)Female (355)Male (452)P value
Age, years73.7 (65.7 to 80.9)75.1 (67.0 to 82.5)72.9 (64.9 to 79.9)0.03
BMI, kg/m228.8 (25.3 to 33.8)29.3 (24.8 to 35.8)28.4 (25.6 to 32.6)0.04
AVA, cm20.86 (0.70 to 1.00)0.80 (0.65 to 0.94)0.90 (0.75 to 1.03)<0.001
AVAi, cm2/m20.43 (0.36 to 0.51)0.44 (0.36 to 0.52)0.43 (0.36 to 0.50)0.09
Vmax, m/s3.87 (3.41 to 4.38)3.80 (3.37 to 4.30)3.92 (3.45 to 4.41)0.02
Mean gradient, mm Hg35.0 (26.7 to 45.3)33.0 (26.0 to 43.1)36.0 (27.5 to 46.0)0.01
Peak gradient, mm Hg59.9 (46.7 to 76.9)57.8 (45.3 to 74.0)61.2 (47.7 to 78.3)0.03
DI0.24 (0.20 to 0.29)0.26 (0.21 to 0.30)0.23 (0.20 to 0.28)<0.001
Ejection fraction, %55 (55 to 63)58 (55 to 63)55 (55 to 60)<0.001
SV, mL78.1 (64.6 to 90.4)73.1 (58.9 to 84.6)81.8 (70.2 to 94.1)<0.001
Indexed SV, mL/m239.7 (32.9 to 46.3)39.9 (33.2 to 47.3)39.4 (32.8 to 45.6)0.22
LVOT diameter, cm2.10 (2.00 to 2.29)2.00 (1.90 to 2.00)2.20 (2.10 to 2.30)<0.001
LVIDd, cm4.42 (3.90 to 4.90)4.10 (3.69 to 4.60)4.61 (4.22 to 5.09)<0.001
LVIDs, cm2.90 (2.50 to 3.46)2.66 (2.31 to 3.10)3.17 (2.76 to 3.62)<0.001
BSA, m21.97 (1.77 to 2.15)1.78 (1.64 to 1.96)2.08 (1.93 to 2.23)<0.001
  • Data presented as median (25th percentile, 75th percentile). 11 female and 16 male patients did not have reliable BMIs recorded, giving n=344‚ÄČand 436 for this metric, respectively. 9 female and 5 male patients did not have LVID metrics, giving n=346‚ÄČand 447, respectively.

  • AVA, aortic valve area; AVAi, indexed AVA; BMI, body mass index; BSA, body surface area; DI, dimensionless index; LVID, left ventricular internal dimension; LVIDd, LVID in diastole; LVIDs, LVID in systole; LVOT, left ventricle outflow tract; SV, stroke volume; Vmax, peak jet velocity.