Baseline patient characteristics, echocardiographic parameters and treatment decisions by number of comorbidities
| All patients (n=2171) | 0 comorbidities* (n=1071) | One comorbidity* (n=735) | ≥2 comorbidities* (n=365) | P value across comorbidity groups | |
| Age (years) | 77.9±10.0 | 75.7±10.7 | 79.4±9.0 | 81.4±7.8 | <0.001 |
| Female gender | 48.0 | 48.0 | 50.2 | 43.3 | 0.097 |
| Severe frailty† | 5.1 | 2.5 | 6.1 | 10.8 | <0.001 |
| EuroSCORE I (%) | 15.6±13.9 | 9.5±8.2 | 17.9±12.8 | 26.8±18.5 | <0.001 |
| EuroSCORE II (%) | 4.0±5.0 | 2.2±3.0 | 4.7±4.7 | 8.2±7.2 | <0.001 |
| Echocardiographic valve parameters | |||||
| Indexed AV area (cm2/m2) | 0.40±5.0 | 0.41±0.11 | 0.39±0.10 | 0.37±0.11 | <0.001 |
| Mean AV gradient (mm Hg) | 47.1±14.7 | 50.0±13.3 | 45.4±14.8 | 42.2±16.3 | <0.001 |
| Mitral regurgitation grade III/IV | 10.7 | 5.2 | 13.6 | 20.4 | <0.001 |
| Tricuspid regurgitation grade III/IV | 7.9 | 3.9 | 8.1 | 18.9 | <0.001 |
| Indexed LV mass (g/m2) | 132.6±40.9 | 126.7±38.0 | 134.4±41.1 | 147.6±44.7 | <0.001 |
| Symptomatic status‡ (%) | 80.3 | 73.6 | 84.4 | 91.8 | <0.001 |
| Severe symptomatic status§ (%) | 51.7 | 40.8 | 58.4 | 70.1 | <0.001 |
| Decision to perform AVR | 69.0 | 67.2 | 71.5 | 69.3 | 0.186 |
| AVR performed within 3 months | 56.3 | 51.5 | 61.5 | 60.5 | <0.001 |
| Time to intervention (days) | 33.0±34.7 | 35.7±36.1 | 30.5±33.6 | 30.8±32.3 | 0.012 |
| Decision to perform TAVI | 45.0 | 35.4 | 54.0 | 57.0 | <0.001 |
| TAVI performed within 3 months | 38.0 | 28.3 | 47.0 | 50.5 | <0.001 |
| Time to intervention (days) | 29.2±34.2 | 30.0±36.4 | 29.2±33.6 | 27.5±31.0 | 0.755 |
| Decision to perform SAVR | 24.0 | 31.9 | 17.4 | 12.3 | <0.001 |
| SAVR performed within 3 months | 18.3 | 23.3 | 14.4 | 10.0 | <0.001 |
| Time to intervention (days) | 40.7±34.5 | 42.4±34.7 | 34.5±33.4 | 46.5±34.4 | 0.037 |
| Decision not to perform AVR | 27.6 | 29.1 | 25.7 | 26.5 | <0.001 |
*LVEF <50%, CKD, AF or COPD.
†Defined as an inability to walk 5 m in ≤6 s and/or to perform activities of daily living.24
‡Defined as chest pain, shortness of breath and/or dizziness on exertion/syncope.
§Defined as CCS class III or IV angina, NYHA class III/IV and/or dizziness on exertion/syncope.
AF, atrial fibrillation; AV, aortic valve; AVA, aortic valve area; AVR, aortic valve replacement; CCS, Canadian Cardiovascular Society; CKD, chronic kidney disease ; COPD, chronic obstructive pulmonary disease; LV, left ventricular; LVEF, left ventricular ejection fraction; NYHA, New York Heart Association; SAVR, surgical AVR; TAVI, transcatheter aortic valve implantation .