Table 2

Association of the most frequent comorbidities with AS symptoms and severity

CKD
(n=2171)
Low LVEF
(n=1071)
AF
(n=735)
COPD
(n=365)
High ES
(n=795)
Symptomatic status1.99 (1.50–2.65)2.58 (1.85–3.58)1.45 (1.04–2.02)2.85 (1.80–4.52)2.55 (1.97–3.31)
 Chest pain1.10 (0.87–1.39)1.25 (0.98–1.59)0.98 (0.73–1.31)1.26 (0.92–1.73)1.66 (1.33–2.07)
 Shortness of breath1.91 (1.49–2.46)2.99 (2.20–4.05)1.53 (1.13–2.07)3.25 (2.12–4.97)2.53 (2.01–3.19)
 Dizziness/syncope1.19 (0.93–1.51)1.53 (1.20–1.97)1.33 (1.00–1.77)1.49 (1.09–2.05)1.48 (1.19–1.85)
Severe symptomatic status*1.98 (1.62–2.44)2.39 (1.92–2.98)1.49 (1.17–1.90)2.06 (1.56–2.73)2.27 (1.88–2.74)
 Angina class III/IV2.33 (1.47–3.70)1.58 (0.98–2.55)0.94 (0.50–1.75)1.46 (0.80–2.69)2.13 (1.34–3.40)
 NYHA class III/IV2.26 (1.85–2.78)2.77 (2.23–3.44)1.43 (1.12–1.83)2.34 (1.78–3.08)2.67 (2.20–3.24)
  • *Includes dizziness/syncope, as listed under symptomatic status.

  • AF, atrial fibrillation; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; ES, EuroSCORE; LVEF, left ventricular ejection fraction; NYHA, New York Heart Association.