Infarct size based on biomarkers
| Clinical endpoints | Low-dose opioids | Intermediate-dose opioids | High-dose opioids | P value |
| Median peak CK (U/L) (IQR) n=420; | 1389 (665–2756) | 1881 (1030–3842) | 2286 (1128–4343) | <0.001 |
| Median AUC72 CK (U/L) (IQR) n=420 | 44 924 (24 264–86 084) | 62 501 (33 752–112 361) | 70 787 (37 789–107 372 | 0.004 |
| Geometric mean peak CK (U/L) (IQR) n=420 | 1339 (665–2697) | 1808 (992–4024) | 2208 (1097–4447) | <0.001 |
| Geometric mean AUC72 CK (U/L) (IQR) n=417 | 49 021 (26 903–98 716) | 73 130 (36 316–133 252) | 80 822 (40 135–120 572) | 0.002 |
| Median peak cTnI (μg/L) (IQR) n=390 | 41 (13–110) | 75 (27–145) | 83 (30–145) | 0.004 |
| Median AUC72 cTnI (μg/L) (IQR) n=388 | 1392 (563–3974) | 2397 (937–5046) | 2757 (966–4827) | 0.002 |
| Geometric mean peak cTnI (μg/L) (IQR) n=390 | 40 (12–110) | 74 (27–148) | 81 (30–148) | 0.004 |
| Geometric mean AUC72 cTnI (μg/L) (IQR) n=387 | 1339 (602–4024) | 2697 (992–5432) | 2981 (1097–5432) | 0.002 |
AUC72, area under the biomarker-time curve up to 72 hours post myocardial infarction; CK, creatine kinase; cTnI, cardiac troponin I.