Baseline characteristics | Low-dose opioids N=115 | Intermediate-dose opioids N=190 | High-dose opioids N=117 | P value |
Age in years, mean (SD) | 67 (12) | 62 (12) | 59 (11) | <0.001 |
Male, n (%) | 80 (70) | 149 (78) | 107 (92) | <0.001 |
Diabetes, n (%) | 18 (16) | 27 (14) | 24 (21) | 0.34 |
Hypertension, n (%) | 73 (64) | 103 (54) | 65 (56) | 0.263 |
Dyslipidaemia, n (%) | 60 (52) | 97 (51) | 72 (62) | 0.175 |
BMI (IQR; n=271) | 26.3 (24–30) | 27.7 (25–30) | 28 (26–36) | 0.014 |
Current or ex-smoking, n (%) (N=419) | 70 (62) | 136 (72) | 88 (75) | 0.069 |
PVD, n (%) | 5 (4) | 6 (3) | 3 (3) | 0.74 |
CVD, n (%) | 9 (8) | 9 (5) | 6 (5) | 0.504 |
IHD, n (%) | 21 (18) | 26 (14) | 30 (26) | 0.031 |
Previous PCI, n (%) | 8 (7) | 16 (8) | 25 (21) | 0.001 |
Previous CABGs, n (%) | 5 (4) | 2 (1) | 0 | 0.024 |
CCF, n (%) | 3 (3) | 5 (3) | 3 (3) | 0.999 |
Creatinine >120 µmol/L, n (%), N=421 | 8 (7) | 13 (7) | 11 (9) | 0.688 |
Prehospital duration in minutes (IQR), N=406 | 50 (42–61) | 54 (47–65) | 64 (53–73) | <0.001 |
Triage time in minutes (IQR), N=401 | 2 (1–5) | 3 (2–5) | 3 (2–5) | 0.290 |
Symptom to intervention time, N=406 | 172 (126–311) | 148 (122–199) | 165 (129–213) | 0.181 |
N denotes total sample size (or sample size within groups)
n denotes numbers within each characteristic for each group
BMI, body mass index; CABG, coronary artery bypass graft surgery; CCF, congestive cardiac failure; CVD, cerebrovascular disease; IHD, ischaemic heart disease; PCI, percutaneous coronary intervention; PVD, peripheral vascular disease.