Table 2

Clinical endpoints

SAPIEN 3ACURATE neoEvolut RLotusP value
n=382n=189n=157n=63
30-day mortality15 (3.9)3 (1.6)7 (4.5)5 (7.9)0.105
Major vascular complication15 (3.9)2 (1.1)4 (2.5)5 (7.9)0.042
Major/life-threatening bleeding21 (5.5)4 (2.1)3 (1.9)6 (9.5)0.019
Stroke8 (2.1)3 (1.6)5 (3.2)3 (4.8)0.397
Early safety38 (9.9)7 (3.7)14 (8.9)12 (19.0)0.002
New permanent pacemaker*36 (11.3)18 (10.4)31 (21.8)20 (37.7)<0.001
ΔPmean post TAVI (mm Hg)12.3±4.79.2±3.98.6±4.313.5±5.0<0.001
  • Values are n (%) or mean±SD.

  • *Patients with pre-existing pacemaker were excluded from these calculations.

  • TAVI, transcatheter aortic valve implantation.