Table 1

Patient characteristics

AllSAPIEN 3ACURATE neoEvolut RLotusP value
n=642n=292n=166n=132n=52
Baseline and procedural characteristics
Age (years)82.0±5.881.2±6.482.9±4.883.1±5.581.4±5.70.01
Female sex374 (58.3)127 (43.5)123 (74.1)96 (92.7)28 (53.8)<0.001
BMI (kg/m²)27.3±8.127.6±10.127.6±5.725.9±5.928.5±6.40.007
BSA (m²)1.82±0.221.87±0.221.79±0.191.74±0.211.89±0.25<0.001
Baseline creatinine (mg/dL)1.27±0.781.34±0.821.19±0.571.19±0.811.40±1.000.007
EuroSCORE I (%)22.8±15.924.3±17.222.1±15.021.5±13.619.8±15.70.122
EuroSCORE II (%)4.6±4.14.8±4.44.3±4.14.3±3.34.7±4.60.791
Pre-existing pacemaker73 (11.4)36 (12.3)16 (9.7)14 (10.6)7 (13.5)0.795
Predilation359 (56.5)128 (44.0)151 (92.6)33 (25.6)47 (90.4)<0.001
Postdilation82 (12.9)12 (4.1)41 (25.2)28 (21.7)1 (1.9)<0.001
Comorbidities
COPD110 (17.1)66 (22.6)21 (12.7)15 (11.4)8 (15.4)0.009
Peripheral artery disease132 (20.6)73 (25.0)33 (19.9)17 (12.9)9 (17.3)0.032
Diabetes200 (31.2)92 (31.5)54 (32.5)39 (29.5)15 (28.8)0.939
Hypertension584 (91)258 (88.4)157 (94.6)121 (91.7)48 (92.3)0.16
Coronary artery disease402 (62.2)174 (59.6)111 (66.9)83 (62.9)34 (65.4)0.464
Previous cardiac surgery124 (19.3)82 (28.1)20 (12.0)20 (15.2)2 (3.8)<0.001
Atrial fibrillation262 (40.9)123 (42.1)63 (38.2)57 (43.2)19 (36.5)0.717
Device landing zone characteristics
Area (mm²)479.9±102.8510.5±104.2454.9±98.9449.4±94.1464.7±80.3<0.001
Perimeter (mm)79.1±8.181.6±8.377.1±7.876.8±7.277.5±6.6<0.001
AVC calcium volume (mm³)616 (406–979)697 (425–1059)581 (359–834)590 (375–879)718 (414–1005)0.009
 NCC (mm³)273 (156–4449)286 (168–481)251 (150–378)253 (149–384)336 (177–514)0.048
 RCC (mm³)175 (96–305)197 (114–333)154 (87–244)165 (87–305)181 (86–337)0.007
 LCC (mm³)157 (89–276)172 (99–323)142 (73–261)142 (88–251)170 (88–251)0.028
LVOT calcium volume (mm³)25 (4–114)28 (4–109)19 (2–98)33 (5–140)24 (2–158)0.488
 LVOTNC (mm³)6 (0–38)6 (0–36)4 (0–31)9 (0–44)7 (0–49)0.341
 LVOTRC (mm³)3 (0–8)0 (0–8)0 (0–8)1 (0–8)0 (0–6)0.811
 LVOTLC (mm³)4 (0–33)4 (0–34)3 (0–16)4 (0–48)6 (0–71)0.672
Total DLZ calcium volume (mm³)683 (441–1073)740 (472–1175)626 (388–882)620 (411–983)819 (434–12 289)0.006
AVC absolute asymmetry (mm³)199±156213±162171±127185±133247±2260.07
LVOT absolute asymmetry (mm³)56±9252±8251±9371±11563±800.456
  • Values are mean±SD, n (%) or median (IQR).

  • AVC, aortic valve cusp; BMI, body mass index; BSA, body surface area; COPD, chronic obstructive pulmonary disease; DLZ, device landing zone; LVOT, left ventricular outflow tract; NCC/RCC/LCC, non-/right/left coronary cusp.