Diagnostic performance of CTCA, excluding small coronary artery segments, for the detection of ≥50% stenosis on ICA
| Prevalence of disease, % | N | TP | FP | FN | TN | Sens, % | Spec, % | PPV, % | NPV, % | |
| Overall | 40 | 826 | 292 | 289 | 36 | 209 | 89 (85–92) | 42 (38–46) | 50 (48–52) | 85 (81–89) |
| Right coronary artery | 12 | 826 | 70 | 146 | 27 | 583 | 72 (62–81) | 80 (77–83) | 32 (28–37) | 96 (94–97) |
| Left main coronary artery | 3 | 826 | 27 | 58 | 1 | 740 | 96 (82–100) | 93 (91–94) | 32 (26–38) | 100 (99–100) |
| Left anterior descending coronary artery | 29 | 826 | 192 | 276 | 43 | 315 | 82 (76–86) | 53 (49–57) | 41 (39–44) | 88 (85–91) |
| Circumflex coronary artery | 9 | 826 | 43 | 121 | 34 | 628 | 56 (44–67) | 84 (81–86) | 26 (22–31) | 95 (93–96) |
Values in parentheses represent upper and lower bound for 95% CI.
CTCA, CT coronary angiography; FN, false-negative; FP, false-positive; ICA, invasive coronary angiography; NPV, negative predictive value; PPV, positive predictive value; sens, sensitivity; spec, specificity; TN, true negative; TP, true positive.