Table 3

Univariate and multivariate analysis of long-term mortality compared with no/trivial TR

VariableUnivariatesMultivariates
HR (95% CI)P valueHR (95% CI)P value
Mild TR1.34 (1.21 to 1.47)<0.0011.07 (0.96 to 1.18)0.213
Moderate TR2.27 (1.94 to 2.65)<0.0011.55 (1.31 to 1.82)<0.001
Severe TR3.10 (2.34 to 4.11)<0.0011.87 (1.40 to 2.50)<0.001
Age >70 years2.66 (2.46 to 2.88)<0.0012.45 (2.25 to 2.66)<0.001
Gender (male)1.43 (1.32 to 1.54)<0.0011.28 (1.18 to 1.39)<0.001
History of heart failure1.75 (1.57 to 1.94)<0.0011.28 (1.13 to 1.43)<0.001
History of IHD1.41 (1.29 to 1.54)<0.0011.01 (0.92 to 1.11)0.859
History of CVA1.29 (1.12 to 1.47)<0.0011.10 (0.95 to 1.26)0.194
Creatinine >2 mg/dL2.12 (1.82 to 2.47)<0.0011.84 (1.57 to 2.15)<0.001
Diabetes mellitus requiring Insulin1.42 (1.22 to 1.64)<0.0011.43 (1.23 to 1.66)<0.001
Elevated risk of surgery1.60 (1.41 to 1.82)<0.0011.45 (1.27 to 1.64)<0.001
LVEF <50%1.96 (1.74 to 2.21)<0.0011.34 (1.18 to 1.54)<0.001
>Moderate MR2.25 (1.95 to 2.59)<0.0011.45 (1.25 to 1.69)<0.001
  • CVA, cerebrovascular accident; IHD, ischaemic heart disease; LVEF, left ventricular ejection fraction; MR, mitral regurgitation; TR, tricuspid regurgitation.